Cell Biology Antibodies 10
Anti-IL-13RA1 Antibody (CAB6628)
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- SKU:
- CAB6628
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | IL13RA1 Rabbit Polyclonal Antibody |
| Antibody SKU: | CAB6628 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 22-343 of human IL13RA1 (NP_001551.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | HT-29, 293T |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 22-343 of human IL13RA1 (NP_001551.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | GGGG AAPT ETQP PVTN LSVS VENL CTVI WTWN PPEG ASSN CSLW YFSH FGDK QDKK IAPE TRRS IEVP LNER ICLQ VGSQ CSTN ESEK PSIL VEKC ISPP EGDP ESAV TELQ CIWH NLSY MKCS WLPG RNTS PDTN YTLY YWHR SLEK IHQC ENIF REGQ YFGC SFDL TKVK DSSF EQHS VQIM VKDN AGKI KPSF NIVP LTSR VKPD PPHI KNLS FHND DLYV QWEN PQNF ISRC LFYE VEVN NSQT ETHN VFYV QEAK CENP EFER NVEN TSCF MVPG VLPD TLNT VRIR VKTN KLCY EDDK LWSN WSQE MSIG KKRN ST |
| Gene ID: | 3597 |
| Uniprot: | P78552 |
| Cellular Location: | Membrane, Single-pass type I membrane protein |
| Calculated MW: | 31kDa/48kDa |
| Observed MW: | 53kDa |
| Synonyms: | IL13RA1, CD213A1, CT19, IL-13Ra, NR4 |
| Background: | The protein encoded by this gene is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. This subunit serves as a primary IL13-binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. This protein has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4. |
| UniProt Protein Function: | IL13R: Binds with low affinity to interleukin-13 (IL13). Together with IL4RA can form a functional receptor for IL13. Also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4 (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding activity. Belongs to the type I cytokine receptor family. Type 5 subfamily. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Receptor, cytokine Chromosomal Location of Human Ortholog: Xq24 Cellular Component: interleukin-13 receptor complex; plasma membrane Molecular Function:hematopoietin/interferon-class (D200-domain) cytokine receptor activity; protein binding Biological Process: cell surface receptor linked signal transduction; cytokine and chemokine mediated signaling pathway |
| NCBI Summary: | The protein encoded by this gene is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. This subunit serves as a primary IL13-binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. This protein has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P78552 |
| NCBI GenInfo Identifier: | 2494718 |
| NCBI Gene ID: | 3597 |
| NCBI Accession: | P78552.1 |
| UniProt Secondary Accession: | P78552,O95646, Q5JSL4, Q99656, Q9UDY5, |
| UniProt Related Accession: | P78552 |
| Molecular Weight: | 31,659 Da |
| NCBI Full Name: | Interleukin-13 receptor subunit alpha-1 |
| NCBI Synonym Full Names: | interleukin 13 receptor subunit alpha 1 |
| NCBI Official Symbol: | IL13RA1 |
| NCBI Official Synonym Symbols: | NR4; CT19; CD213A1; IL-13Ra |
| NCBI Protein Information: | interleukin-13 receptor subunit alpha-1 |
| UniProt Protein Name: | Interleukin-13 receptor subunit alpha-1 |
| UniProt Synonym Protein Names: | Cancer/testis antigen 19; CT19; CD_antigen: CD213a1 |
| Protein Family: | Interleukin-13 receptor |
| UniProt Gene Name: | IL13RA1 |
| UniProt Entry Name: | I13R1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using IL13RA1 antibody (CAB6628) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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