Anti-IKZF3 Antibody (CAB8614)
- SKU:
- CAB8614
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- AIO
- Synonyms:
- AIOLOS
- Synonyms:
- ZNFN1A3
- Research Area:
- Immunology
Description
| Product Name: | IKZF3 Rabbit mAb |
| Product Code: | CAB8614 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | AIO, AIOLOS, ZNFN1A3 |
| Applications: | WB, IHC, IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human IKZF3 |
| Applications: | WB, IHC, IF |
| Recommended Dilutions: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Raji, Mouse spleen, Mouse thymus, Rat lung |
| Immunogen: | A synthesized peptide derived from human IKZF3 |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 22806 |
| Uniprot: | Q9UKT9 |
| Calculated MW: | 70kDa |
| Observed MW: | 50-70KDa |
| UniProt Protein Function: | Aiolos: a transcription factor of the ikaros C2H2-type zinc-finger protein family. Plays an important role in the regulation of lymphocyte differentiation. Deletions in Aiolos have been observed in a subset of pre-B-cell acute lymphoblastic leukemia (B-ALL) cases. 6 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:C2H2-type zinc finger protein; DNA-binding; Transcription factor Chromosomal Location of Human Ortholog: 17q21 Cellular Component: cytoplasm; plasma membrane; nucleus Molecular Function:protein binding; protein homodimerization activity; protein heterodimerization activity; sequence-specific DNA binding; metal ion binding; transcription factor activity Biological Process: regulation of apoptosis; regulation of transcription from RNA polymerase II promoter; B cell activation; transcription, DNA-dependent; regulation of lymphocyte differentiation; regulation of B cell differentiation; regulation of B cell proliferation; mesoderm development |
| NCBI Summary: | This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non-protein coding variants. [provided by RefSeq, Apr 2012] |
| UniProt Code: | Q9UKT9 |
| NCBI GenInfo Identifier: | 212276437 |
| NCBI Gene ID: | 22806 |
| NCBI Accession: | Q9UKT9.2 |
| UniProt Secondary Accession: | Q9UKT9,Q69BL6, Q69BL7, Q69BL8, Q69BL9, Q69BM0, Q69BM1 Q69BM2, Q69BM3, Q69BM5, Q8N574, B4DVV5, |
| UniProt Related Accession: | Q9UKT9 |
| Molecular Weight: | 509 |
| NCBI Full Name: | Zinc finger protein Aiolos |
| NCBI Synonym Full Names: | IKAROS family zinc finger 3 (Aiolos) |
| NCBI Official Symbol: | IKZF3 |
| NCBI Official Synonym Symbols: | AIO; AIOLOS; ZNFN1A3 |
| NCBI Protein Information: | zinc finger protein Aiolos; zinc finger DNA binding protein Aiolos; zinc finger protein, subfamily 1A, 3 (Aiolos) |
| UniProt Protein Name: | Zinc finger protein Aiolos |
| UniProt Synonym Protein Names: | Ikaros family zinc finger protein 3 |
| Protein Family: | Zinc finger protein |
| UniProt Gene Name: | IKZF3 |
| UniProt Entry Name: | IKZF3_HUMAN |
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