Epigenetics & Nuclear Signaling Antibodies 2
Anti-IKKEpsilon Antibody (CAB16470)
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- SKU:
- CAB16470
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | IKK? Rabbit Polyclonal Antibody |
| Antibody SKU: | CAB16470 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IP |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 460-620 of human IKK? (NP_001180251.1). |
| Application: | WB IHC IP |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IP 1:50 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: | K-562 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 460-620 of human IKK? (NP_001180251.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | VART SLLY LSSS LGTE RFSS VAGT PEIQ ELKA AAEL RSRL RTLA EVLS RCSQ NITE TQES LSSL NREL VKSR DQVH EDRS IQQI QCCL DKMN FIYK QFKK SRMR PGLG YNEE QIHK LDKV NFSH LAKR LLQV FQEE CVQK YQAS LVTH GKRM RVVH ETRN H |
| Gene ID: | 9641 |
| Uniprot: | Q14164 |
| Cellular Location: | Cytoplasm, Nucleus, PML body |
| Calculated MW: | 70kDa/80kDa |
| Observed MW: | 110kDa |
| Synonyms: | IKBKE, IKK-E, IKK-i, IKKE, IKKI |
| Background: | IKBKE is a noncanonical I-kappa-B (see MIM 164008) kinase (IKK) that is essential for regulating antiviral signaling pathways. IKBKE has also been identified as a breast cancer (MIM 114480) oncogene and is amplified and overexpressed in over 30% of breast carcinomas and breast cancer cell lines. |
| UniProt Protein Function: | IKKE: a oncogenic kinase of the IKK family. Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Plays a pivotal role in coordinating the activation of IRF3 and NF-kappaB in the innate immune response. Its redistribution to PML nuclear bodies upon DNA damage is TOPORS-dependent. Is a breast cancer oncogene that exerts its oncogenic properties through cRel. |
| UniProt Protein Details: | Protein type:Inhibitor; Kinase, protein; EC 2.7.11.10; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Other group; IKK family Chromosomal Location of Human Ortholog: 1q32.1 Cellular Component: nucleoplasm; PML body; cytoplasm; mitochondrial membrane; endosome membrane; nucleus; cytosol Molecular Function:NF-kappaB-inducing kinase activity; protein binding; IkappaB kinase activity; ATP binding Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; DNA damage response, signal transduction resulting in induction of apoptosis; MyD88-independent toll-like receptor signaling pathway; toll-like receptor signaling pathway; innate immune response; immune response; toll-like receptor 3 signaling pathway; I-kappaB phosphorylation; negative regulation of interferon type I production; toll-like receptor 4 signaling pathway; protein amino acid phosphorylation |
| NCBI Summary: | IKBKE is a noncanonical I-kappa-B (see MIM 164008) kinase (IKK) that is essential for regulating antiviral signaling pathways. IKBKE has also been identified as a breast cancer (MIM 114480) oncogene and is amplified and overexpressed in over 30% of breast carcinomas and breast cancer cell lines (Hutti et al., 2009 [PubMed 19481526]).[supplied by OMIM, Oct 2009] |
| UniProt Code: | Q14164 |
| NCBI GenInfo Identifier: | 14548079 |
| NCBI Gene ID: | 9641 |
| NCBI Accession: | Q14164.1 |
| UniProt Secondary Accession: | Q14164,Q3B754, Q3KR43, Q5JTS6, D3DT78, |
| UniProt Related Accession: | Q14164 |
| Molecular Weight: | 716 |
| NCBI Full Name: | Inhibitor of nuclear factor kappa-B kinase subunit epsilon |
| NCBI Synonym Full Names: | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon |
| NCBI Official Symbol: | IKBKE |
| NCBI Official Synonym Symbols: | IKKE; IKKI; IKK-E; IKK-i |
| NCBI Protein Information: | inhibitor of nuclear factor kappa-B kinase subunit epsilon; IKK-epsilon; I-kappa-B kinase epsilon; inducible IkappaB kinase; IKK-related kinase epsilon; inducible I kappa-B kinase |
| UniProt Protein Name: | Inhibitor of nuclear factor kappa-B kinase subunit epsilon |
| UniProt Synonym Protein Names: | Inducible I kappa-B kinase; IKK-i |
| UniProt Gene Name: | IKBKE |
| UniProt Entry Name: | IKKE_HUMAN |
 | Immunoprecipitation analysis of 200ug extracts of K-562 cells, using 3 ug IKKe antibody (CAB16470). Western blot was performed from the immunoprecipitate using IKKe antibody (CAB16470) at a dilition of 1:1000. |
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