Immunology Antibodies 1

Anti-IK Antibody (CAB15280)

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SKU:
CAB15280
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology

Description

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Antibody Name:Anti-IK Antibody
Antibody SKU:CAB15280
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human IK (NP_006074.2).
Application:WB
Recommended Dilution:WB 1:200 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:A-549, HeLa, LO2, Mouse brain, Mouse testis, Rat kidney
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human IK (NP_006074.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MPER DSEP FSNP LAPD GHDV DDPH SFHQ SKLT NEDF RKLL MTPR AAPT SAPP SKSR HHEM PREY NEDE DPAA RRRK KKSY YAKL RQQE IERE RELA EKYR DRAK ERRD GVNK DYEE TELI STTA NYRA VGPT AEAD KSAA EKRR QLIQ ESKF LGGD MEHT HLVK GLDF ALLQ KVRA EIAS KEKE EEEL MEKP QKET KKDE DPEN KIEF KTRL GRNV YRML FKSK AYER NELF LPGR MAYV VDLD DEYA DTDI PTTL IRSK ADCP TMEA QTTL TTND IVIS
Gene ID:3550
Uniprot:Q13123
Cellular Location:Nucleus
Calculated MW:65kDa
Observed MW:75kDa
Synonyms:IK, CSA2, RED, RER
Background:The protein encoded by this gene was identified by its RED repeat, a stretch of repeated arginine, glutamic acid and aspartic acid residues. The protein localizes to discrete dots within the nucleus, excluding the nucleolus. Its function is unknown. This gene maps to chromosome 5; however, a pseudogene may exist on chromosome 2.
UniProt Protein Function:Involved in pre-mRNA splicing as a component of the spliceosome (PubMed:28781166). Auxiliary spliceosomal protein that regulates selection of alternative splice sites in a small set of target pre-mRNA species (Probable). Required for normal mitotic cell cycle progression (PubMed:22351768, PubMed:24252166). Recruits MAD1L1 and MAD2L1 to kinetochores, and is required to trigger the spindle assembly checkpoint (PubMed:22351768). Required for normal accumulation of SMU1 (PubMed:24945353).
NCBI Summary:The protein encoded by this gene was identified by its RED repeat, a stretch of repeated arginine, glutamic acid and aspartic acid residues. The protein localizes to discrete dots within the nucleus, excluding the nucleolus. Its function is unknown. This gene maps to chromosome 5; however, a pseudogene may exist on chromosome 2. [provided by RefSeq, Jul 2008]
UniProt Code:Q13123
NCBI GenInfo Identifier:125988409
NCBI Gene ID:3550
NCBI Accession:NP_006074.2
UniProt Secondary Accession:Q13123,Q6IPD8,
UniProt Related Accession:Q13123
Molecular Weight:65,602 Da
NCBI Full Name:protein Red
NCBI Synonym Full Names:IK cytokine
NCBI Official Symbol:IK  
NCBI Official Synonym Symbols:RED; RER; CSA2  
NCBI Protein Information:protein Red
UniProt Protein Name:Protein Red
UniProt Synonym Protein Names:Cytokine IK
Protein Family:Ikitoxin
UniProt Gene Name:IK  
Anti-IK Antibody (CAB15280)Western blot analysis of extracts of various cell lines, using IK antibody (CAB15280) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 15S.
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