Cell Biology Antibodies 10

Anti-IHH Antibody (CAB6626)

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SKU:
CAB6626
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-IHH Antibody
Antibody SKU:CAB6626
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 202-411 of human IHH (NP_002172.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:Human placenta, Mouse kidney, Mouse liver, Mouse ovary, Rat liver, Rat lung, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 202-411 of human IHH (NP_002172.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:GCFP AGAQ VRLE SGAR VALS AVRP GDRV LAMG EDGS PTFS DVLI FLDR EPHR LRAF QVIE TQDP PRRL ALTP AHLL FTAD NHTE PAAR FRAT FASH VQPG QYVL VAGV PGLQ PARV AAVS THVA LGAY APLT KHGT LVVE DVVA SCFA AVAD HHLA QLAF WPLR LFHS LAWG SWTP GEGV HWYP QLLY RLGR LLLE EGSF HPLG MSGA GS
Gene ID:3549
Uniprot:Q14623
Cellular Location:Cell membrane, Extracellular side, Lipid-anchor, Secreted, extracellular space
Calculated MW:45kDa
Observed MW:53kDa
Synonyms:IHH, BDA1, HHG2
Background:This gene encodes a member of the hedgehog family of proteins. The encoded preproprotein is proteolytically processed to generate multiple protein products, including an N-terminal fragment that is involved in signaling. Hedgehog family proteins are essential secreted signaling molecules that regulate a variety of developmental processes including growth, patterning and morphogenesis. The protein encoded by this gene specifically plays a role in bone growth and differentiation. Mutations in this gene are the cause of brachydactyly type A1, which is characterized by shortening or malformation of the fingers and toes. Mutations in this gene are also the cause of acrocapitofemoral dysplasia.
UniProt Protein Function:IHH: Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP). Expressed in embryonic lung, and in adult kidney and liver. Belongs to the hedgehog family.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 2q33-q35

Cellular Component: extracellular matrix; extracellular space; plasma membrane

Molecular Function:peptidase activity; patched binding; calcium ion binding

Biological Process: vitelline membrane formation; proteoglycan metabolic process; maternal process involved in pregnancy; cell maturation; positive regulation of collagen biosynthetic process; cell fate specification; proteolysis; embryonic pattern specification; response to estradiol stimulus; positive regulation of T cell differentiation in the thymus; smooth muscle development; cell-cell signaling; embryonic digestive tract morphogenesis; regulation of growth; pancreas development; positive regulation of mesenchymal cell proliferation; positive regulation of smoothened signaling pathway; heart looping; skeletal development; bone resorption; negative regulation of immature T cell proliferation in the thymus; smoothened signaling pathway; intein-mediated protein splicing; in utero embryonic development; multicellular organism growth; negative regulation of eye pigmentation; negative regulation of T cell differentiation in the thymus; negative regulation of signal transduction; patterning of blood vessels; osteoblast differentiation; positive regulation of chondrocyte differentiation; cartilage development; neuron development; positive regulation of transcription from RNA polymerase II promoter; embryonic digit morphogenesis; embryonic camera-type eye morphogenesis; positive regulation of alpha-beta T cell differentiation; positive regulation of epithelial cell proliferation; negative regulation of apoptosis; negative regulation of alpha-beta T cell differentiation

Disease: Brachydactyly, Type A1; Acrocapitofemoral Dysplasia

NCBI Summary:This gene encodes a member of the hedgehog family of secreted signaling molecules. Hedgehog proteins are essential regulators of a variety of developmental processes including growth, patterning and morphogenesis. The encoded protein specifically plays a role in bone growth an differentiation. Mutations in this gene are the cause of brachydactyly type A1 which is characterized by shortening or malformation of the phalanges. Mutations in this gene are also the cause of acrocapitofemoral dysplasia. [provided by RefSeq, Feb 2010]
UniProt Code:Q14623
NCBI GenInfo Identifier:33112634
NCBI Gene ID:3549
NCBI Accession:Q14623.4
UniProt Secondary Accession:Q14623,O43322, Q8N4B9, B9EGM5,
UniProt Related Accession:Q14623
Molecular Weight:45,251 Da
NCBI Full Name:Indian hedgehog protein
NCBI Synonym Full Names:indian hedgehog
NCBI Official Symbol:IHH  
NCBI Official Synonym Symbols:BDA1; HHG2  
NCBI Protein Information:indian hedgehog protein; HHG-2; Indian hedgehog homolog
UniProt Protein Name:Indian hedgehog protein
UniProt Synonym Protein Names:HHG-2Cleaved into the following 2 chains:Indian hedgehog protein N-product; Indian hedgehog protein C-product
Protein Family:Indian hedgehog protein
UniProt Gene Name:IHH  
UniProt Entry Name:IHH_HUMAN
Anti-IHH Antibody (CAB6626)Western blot analysis of extracts of various cell lines, using IHH antibody (CAB6626) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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