Cell Biology Antibodies 4
Anti-IGSF8 Antibody (CAB14297)
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- SKU:
- CAB14297
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-IGSF8 Antibody |
| Antibody SKU: | CAB14297 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 28-350 of human IGSF8 (NP_443100.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Raji |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 28-350 of human IGSF8 (NP_443100.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | REVL VPEG PLYR VAGT AVSI SCNV TGYE GPAQ QNFE WFLY RPEA PDTA LGIV STKD TQFS YAVF KSRV VAGE VQVQ RLQG DAVV LKIA RLQA QDAG IYEC HTPS TDTR YLGS YSGK VELR VLPD VLQV SAAP PGPR GRQA PTSP PRMT VHEG QELA LGCL ARTS TQKH THLA VSFG RSVP EAPV GRST LQEV VGIR SDLA VEAG APYA ERLA AGEL RLGK EGTD RYRM VVGG AQAG DAGT YHCT AAEW IQDP DGSW AQIA EKRA VLAH VDVQ TLSS QLAV TVGP GERR IGPG EPLE LLCN VSGA LPPA GRHA AYSV GWEM APA |
| Gene ID: | 93185 |
| Uniprot: | Q969P0 |
| Cellular Location: | Cell membrane, Single-pass membrane protein |
| Calculated MW: | 40kDa/55kDa/65kDa |
| Observed MW: | 65kDa |
| Synonyms: | IGSF8, CD316, CD81P3, EWI-2, EWI2, KCT-4, LIR-D1, PGRL |
| Background: | This gene encodes a member the EWI subfamily of the immunoglobulin protein superfamily. Members of this family contain a single transmembrane domain, an EWI (Glu-Trp-Ile)-motif and a variable number of immunoglobulin domains. This protein interacts with the tetraspanins CD81 and CD9 and may regulate their role in certain cellular functions including cell migration and viral infection. The encoded protein may also function as a tumor suppressor by inhibiting the proliferation of certain cancers. Alternate splicing results in multiple transcript variants that encode the same protein. |
| UniProt Protein Function: | IGSF8: May play a key role in diverse functions ascribed to CD81 and CD9 such as oocytes fertilization or hepatitis C virus function. May regulate proliferation and differentiation of keratinocytes. May be a negative regulator of cell motility: suppresses T-cell mobility coordinately with CD81, associates with CD82 to suppress prostate cancer cell migration, regulates epidermoid cell reaggregation and motility on laminin-5 with CD9 and CD81 as key linkers. May also play a role on integrin- dependent morphology and motility functions. May participate in the regulation of neurite outgrowth and maintenance of the neural network in the adult brain. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Immunoglobulin superfamily; Membrane protein, integral Chromosomal Location of Human Ortholog: 1q23.1 Cellular Component: integral to membrane; membrane Molecular Function:protein binding |
| NCBI Summary: | This gene encodes a member the EWI subfamily of the immunoglobulin protein superfamily. Members of this family contain a single transmembrane domain, an EWI (Glu-Trp-Ile)-motif and a variable number of immunoglobulin domains. This protein interacts with the tetraspanins CD81 and CD9 and may regulate their role in certain cellular functions including cell migration and viral infection. The encoded protein may also function as a tumor suppressor by inhibiting the proliferation of certain cancers. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011] |
| UniProt Code: | Q969P0 |
| NCBI GenInfo Identifier: | 74762642 |
| NCBI Gene ID: | 93185 |
| NCBI Accession: | Q969P0.1 |
| UniProt Secondary Accession: | Q969P0,Q8NG09, Q96DP4, Q9BTG9, |
| UniProt Related Accession: | Q969P0 |
| Molecular Weight: | 55,808 Da |
| NCBI Full Name: | Immunoglobulin superfamily member 8 |
| NCBI Synonym Full Names: | immunoglobulin superfamily member 8 |
| NCBI Official Symbol: | IGSF8 |
| NCBI Official Synonym Symbols: | EWI2; PGRL; CD316; EWI-2; KCT-4; CD81P3; LIR-D1 |
| NCBI Protein Information: | immunoglobulin superfamily member 8 |
| UniProt Protein Name: | Immunoglobulin superfamily member 8 |
| UniProt Synonym Protein Names: | CD81 partner 3; Glu-Trp-Ile EWI motif-containing protein 2; EWI-2; Keratinocytes-associated transmembrane protein 4; KCT-4; LIR-D1; Prostaglandin regulatory-like protein; PGRL; CD_antigen: CD316 |
| Protein Family: | Immunoglobulin superfamily |
| UniProt Gene Name: | IGSF8 |
| UniProt Entry Name: | IGSF8_HUMAN |
 | Western blot analysis of extracts of Raji cells, using IGSF8 antibody (CAB14297) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 10s. |
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