Epigenetics & Nuclear Signaling Antibodies 2
Anti-IGHMBP2 Antibody (CAB16053)
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- SKU:
- CAB16053
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-IGHMBP2 Antibody |
| Antibody SKU: | CAB16053 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 540-720 of human IGHMBP2 (NP_002171.2). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HepG2, A-549, Mouse brain, Mouse testis, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 540-720 of human IGHMBP2 (NP_002171.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | PYNL QVDL LRQS LVHR HPEL EIKS VDGF QGRE KEAV ILSF VRSN RKGE VGFL AEDR RINV AVTR ARRH VAVI CDSR TVNN HAFL KTLV EYFT QHGE VRTA FEYL DDIV PENY SHEN SQGS SHAA TKPQ GPAT STRT GSQR QEGG QEAA APAR QGRK KPAG KSLA SEAP SQPS LNGG SPEG V |
| Gene ID: | 3508 |
| Uniprot: | P38935 |
| Cellular Location: | Cell projection, Cytoplasm, Nucleus, axon |
| Calculated MW: | 109kDa |
| Observed MW: | 109kDa |
| Synonyms: | IGHMBP2, CATF1, CMT2S, HCSA, HMN6, SMARD1, SMUBP2, ZFAND7 |
| Background: | This gene encodes a helicase superfamily member that binds a specific DNA sequence from the immunoglobulin mu chain switch region. Mutations in this gene lead to spinal muscle atrophy with respiratory distress type 1. |
| UniProt Protein Function: | 5' to 3' helicase that unwinds RNA and DNA duplices in an ATP-dependent reaction. Acts as a transcription regulator. Required for the transcriptional activation of the flounder liver-type antifreeze protein gene. Exhibits strong binding specificity to the enhancer element B of the flounder antifreeze protein gene intron. Binds to the insulin II gene RIPE3B enhancer region. May be involved in translation. DNA-binding protein specific to 5'-phosphorylated single-stranded guanine-rich sequence related to the immunoglobulin mu chain switch region. Preferentially binds to the 5'-GGGCT-3' motif. Interacts with tRNA-Tyr. Stimulates the transcription of the human neurotropic virus JCV. |
| NCBI Summary: | This gene encodes a helicase superfamily member that binds a specific DNA sequence from the immunoglobulin mu chain switch region. Mutations in this gene lead to spinal muscle atrophy with respiratory distress type 1. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P38935 |
| NCBI GenInfo Identifier: | 119392094 |
| NCBI Gene ID: | 3508 |
| NCBI Accession: | NP_002171.2 |
| UniProt Secondary Accession: | P38935,Q00443, Q14177, A0PJD2, |
| UniProt Related Accession: | P38935 |
| Molecular Weight: | 109 |
| NCBI Full Name: | DNA-binding protein SMUBP-2 |
| NCBI Synonym Full Names: | immunoglobulin mu binding protein 2 |
| NCBI Official Symbol: | IGHMBP2 |
| NCBI Official Synonym Symbols: | HCSA; HMN6; CATF1; CMT2S; SMARD1; SMUBP2; ZFAND7 |
| NCBI Protein Information: | DNA-binding protein SMUBP-2 |
| UniProt Protein Name: | DNA-binding protein SMUBP-2 |
| UniProt Synonym Protein Names: | ATP-dependent helicase IGHMBP2; Glial factor 1; GF-1; Immunoglobulin mu-binding protein 2 |
| UniProt Gene Name: | IGHMBP2 |
 | Western blot analysis of extracts of various cell lines, using IGHMBP2 antibody (CAB16053) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
 | Immunohistochemistry of paraffin-embedded rat brain using IGHMBP2 antibody (CAB16053) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human lung cancer using IGHMBP2 antibody (CAB16053) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human mammary cancer using IGHMBP2 antibody (CAB16053) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse liver using IGHMBP2 antibody (CAB16053) at dilution of 1:100 (40x lens). |
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