Description
Product Name: | IGHD Rabbit mAb |
Product Code: | CAB19708 |
Size: | 20uL, 50uL, 100uL |
Applications: | WB |
Reactivity: | Human |
Host Species: | Rabbit |
Immunogen: | A synthesized peptide derived from human IGHD |
Applications: | WB |
Recommended Dilutions: | WB 1:500 - 1:2000 |
Reactivity: | Human |
Positive Samples: | Human plasma |
Immunogen: | A synthesized peptide derived from human IGHD |
Purification Method: | Affinity purification |
Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | Email for sequence |
Gene ID: | 3495 |
Uniprot: | P01880 |
Calculated MW: | 84kDa |
Observed MW: | 55KDa |
UniProt Protein Function: | IGHD: IgD is the major antigen receptor isotype on the surface of most peripheral B-cells, where it is coexpressed with IgM. The membrane-bound IgD (mIgD) induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. Soluble IgD (sIgD) concentration in serum below those of IgG, IgA, and IgM but much higher than that of IgE. IgM and IgD molecules present on B cells have identical V regions and antigen-binding sites. After the antigen binds to the B-cell receptor, the secreted form sIgD is shut off. IgD is a potent inducer of TNF, IL1B, and IL1RN. IgD also induces release of IL6, IL10, and LIF from peripheral blood mononuclear cells. Monocytes seem to be the main producers of cytokines in vitro in the presence of IgD. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Chromosomal Location of Human Ortholog: 14q32.33 Cellular Component: integral to membrane; plasma membrane Molecular Function:antigen binding Biological Process: immune response |
UniProt Code: | P01880 |
NCBI GenInfo Identifier: | 193806360 |
NCBI Gene ID: | 3495 |
NCBI Accession: | P01880.2 |
UniProt Secondary Accession: | P01880,Q6P4I8, Q8WU38, |
UniProt Related Accession: | P01880 |
Molecular Weight: | 47,401 Da |
NCBI Full Name: | Ig delta chain C region, partial |
NCBI Synonym Full Names: | immunoglobulin heavy constant delta |
NCBI Official Symbol: | IGHD |
UniProt Protein Name: | Ig delta chain C region |
UniProt Gene Name: | IGHD |
UniProt Entry Name: | IGHD_HUMAN |