Cell Biology Antibodies 1
Anti-IGFBP6 Antibody (CAB10195)
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- SKU:
- CAB10195
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-IGFBP6 Antibody |
| Antibody SKU: | CAB10195 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 28-240 of human IGFBP6 (NP_002169.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:1000 - 1:3000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | SW480, Mouse liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 28-240 of human IGFBP6 (NP_002169.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | RCPG CGQG VQAG CPGG CVEE EDGG SPAE GCAE AEGC LRRE GQEC GVYT PNCA PGLQ CHPP KDDE APLR ALLL GRGR CLPA RAPA VAEE NPKE SKPQ AGTA RPQD VNRR DQQR NPGT STTP SQPN SAGV QDTE MGPC RRHL DSVL QQLQ TEVY RGAQ TLYV PNCD HRGF YRKR QCRS SQGQ RRGP CWCV DRMG KSLP GSPD GNGS SSCP TGSS G |
| Gene ID: | 3489 |
| Uniprot: | P24592 |
| Cellular Location: | Secreted |
| Calculated MW: | 25kDa |
| Observed MW: | 25kDa |
| Synonyms: | IGFBP6, IBP6 |
| Background: |
| UniProt Protein Function: | IGFBP6: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. |
| UniProt Protein Details: | Protein type:Cell cycle regulation; Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 12q13 Cellular Component: Golgi apparatus; extracellular space; extracellular region Molecular Function:insulin-like growth factor I binding; insulin-like growth factor II binding Biological Process: negative regulation of cell proliferation; regulation of insulin-like growth factor receptor signaling pathway; cellular protein metabolic process; regulation of cell growth; signal transduction |
| UniProt Code: | P24592 |
| NCBI GenInfo Identifier: | 124068 |
| NCBI Gene ID: | 3489 |
| NCBI Accession: | P24592.1 |
| UniProt Secondary Accession: | P24592,Q14492, |
| UniProt Related Accession: | P24592 |
| Molecular Weight: | 25,322 Da |
| NCBI Full Name: | Insulin-like growth factor-binding protein 6 |
| NCBI Synonym Full Names: | insulin-like growth factor binding protein 6 |
| NCBI Official Symbol: | IGFBP6 |
| NCBI Official Synonym Symbols: | IBP6 |
| NCBI Protein Information: | insulin-like growth factor-binding protein 6; IBP-6; IGFBP-6; IGF binding protein 6; IGF-binding protein 6 |
| UniProt Protein Name: | Insulin-like growth factor-binding protein 6 |
| Protein Family: | Insulin-like growth factor-binding protein |
| UniProt Gene Name: | IGFBP6 |
| UniProt Entry Name: | IBP6_HUMAN |
 | Western blot analysis of extracts of various cell lines, using IGFBP6 antibody (CAB10195) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s. |
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