Developmental Biology

Anti-IGFBP2 Antibody (CAB0403)

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SKU:
CAB0403
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Developmental Biology

Description

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Antibody Name:Anti-IGFBP2 Antibody
Antibody SKU:CAB0403
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 100-200 of human IGFBP2 (NP_000588.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:LO2, HeLa, SW480
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 100-200 of human IGFBP2 (NP_000588.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:ACGV YTPR CGQG LRCY PHPG SELP LQAL VMGE GTCE KRRD AEYG ASPE QVAD NGDD HSEG GLVE NHVD STMN MLGG GGSA GRKP LKSG MKEL AVFR EKVT E
Gene ID:3485
Uniprot:P18065
Cellular Location:Secreted
Calculated MW:34kDa
Observed MW:37kDa
Synonyms:IGFBP2, IBP2, IGF-BP53
Background:The protein encoded by this gene is one of six similar proteins that bind insulin-like growth factors I and II (IGF-I and IGF-II). The encoded protein can be secreted into the bloodstream, where it binds IGF-I and IGF-II with high affinity, or it can remain intracellular, interacting with many different ligands. High expression levels of this protein promote the growth of several types of tumors and may be predictive of the chances of recovery of the patient. Several transcript variants, one encoding a secreted isoform and the others encoding nonsecreted isoforms, have been found for this gene.
UniProt Protein Function:IGFBP2: Inhibits IGF-mediated growth and developmental rates. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Binds IGF2 more than IGF1.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 2q35

Cellular Component: extracellular space; apical plasma membrane; extracellular region; cytoplasmic vesicle

Molecular Function:protein binding; insulin-like growth factor I binding; insulin-like growth factor II binding

Biological Process: response to drug; regulation of insulin-like growth factor receptor signaling pathway; response to retinoic acid; response to lithium ion; response to glucocorticoid stimulus; female pregnancy; positive regulation of activated T cell proliferation; signal transduction; response to estradiol stimulus; cellular response to hormone stimulus; cellular protein metabolic process; response to mechanical stimulus; regulation of cell growth; response to nutrient; aging

UniProt Code:P18065
NCBI GenInfo Identifier:290457647
NCBI Gene ID:3485
NCBI Accession:P18065.2
UniProt Secondary Accession:P18065,Q14619, Q9UCL3,
UniProt Related Accession:P18065
Molecular Weight:34,814 Da
NCBI Full Name:Insulin-like growth factor-binding protein 2
NCBI Synonym Full Names:insulin-like growth factor binding protein 2, 36kDa
NCBI Official Symbol:IGFBP2  
NCBI Official Synonym Symbols:IBP2; IGF-BP53  
NCBI Protein Information:insulin-like growth factor-binding protein 2; IBP-2; IGFBP-2; IGF-binding protein 2
UniProt Protein Name:Insulin-like growth factor-binding protein 2
Protein Family:Insulin-like growth factor-binding protein
UniProt Gene Name:IGFBP2  
UniProt Entry Name:IBP2_HUMAN
Anti-IGFBP2 Antibody (CAB0403)Western blot analysis of extracts of various cell lines, using IGFBP2 antibody (CAB0403) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 30s.
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