Cell Biology Antibodies 2
Anti-IGFBP1 Antibody (CAB11109)
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- SKU:
- CAB11109
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-IGFBP1 Antibody |
| Antibody SKU: | CAB11109 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 150-250 of human IGFBP1 (NP_000587.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse liver, Mouse kidney, Rat liver |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 150-250 of human IGFBP1 (NP_000587.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | ILWD AIST YDGS KALH VTNI KKWK EPCR IELY RVVE SLAK AQET SGEE ISKF YLPN CNKN GFYH SRQC ETSM DGEA GLCW CVYP WNGK RIPG SPEI RGDP N |
| Gene ID: | 3484 |
| Uniprot: | P08833 |
| Cellular Location: | Secreted |
| Calculated MW: | 27kDa |
| Observed MW: | 28kDa |
| Synonyms: | IGFBP1, AFBP, IBP1, IGF-BP25, PP12, hIGFBP-1 |
| Background: | This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. |
| UniProt Protein Function: | IGFBP1: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 7p12.3 Cellular Component: extracellular region; extracellular space Molecular Function:insulin-like growth factor binding; insulin-like growth factor I binding; insulin-like growth factor II binding Biological Process: cellular protein metabolic process; insulin receptor signaling pathway; positive regulation of cell growth; regulation of insulin-like growth factor receptor signaling pathway; signal transduction; tissue regeneration; unfolded protein response |
| NCBI Summary: | This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P08833 |
| NCBI GenInfo Identifier: | 124055 |
| NCBI Gene ID: | 3484 |
| NCBI Accession: | P08833.1 |
| UniProt Secondary Accession: | P08833,Q8IYP5, A4D2F4, D3DVL9, |
| UniProt Related Accession: | P08833 |
| Molecular Weight: | 27,904 Da |
| NCBI Full Name: | Insulin-like growth factor-binding protein 1 |
| NCBI Synonym Full Names: | insulin like growth factor binding protein 1 |
| NCBI Official Symbol: | IGFBP1 |
| NCBI Official Synonym Symbols: | AFBP; IBP1; PP12; IGF-BP25; hIGFBP-1 |
| NCBI Protein Information: | insulin-like growth factor-binding protein 1 |
| UniProt Protein Name: | Insulin-like growth factor-binding protein 1 |
| UniProt Synonym Protein Names: | Placental protein 12; PP12 |
| Protein Family: | Insulin-like growth factor-binding protein |
| UniProt Gene Name: | IGFBP1 |
| UniProt Entry Name: | IBP1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using IGFBP1 antibody (CAB11109) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
 | Immunohistochemistry of paraffin-embedded rat spleen using IGFBP1 antibody (CAB11109) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human liver cancer using IGFBP1 antibody (CAB11109) at dilution of 1:100 (40x lens). |
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