Cell Biology Antibodies 1

Anti-IGFALS Antibody (CAB10223)

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SKU:
CAB10223
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-IGFALS Antibody
Antibody SKU:CAB10223
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 396-605 of human IGFALS (NP_004961.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:Mouse lung, Rat liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 396-605 of human IGFALS (NP_004961.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:SCLG RIRP HTFT GLSG LRRL FLKD NGLV GIEE QSLW GLAE LLEL DLTS NQLT HLPH RLFQ GLGK LEYL LLSR NRLA ELPA DALG PLQR AFWL DVSH NRLE ALPN SLLA PLGR LRYL SLRN NSLR TFTP QPPG LERL WLEG NPWD CGCP LKAL RDFA LQNP SAVP RFVQ AICE GDDC QPPA YTYN NITC ASPP EVVG LDLR DLSE AHFA PC
Gene ID:3483
Uniprot:P35858
Cellular Location:Secreted, extracellular space
Calculated MW:66kDa/70kDa
Observed MW:66kDa/72kDa
Synonyms:IGFALS, ACLSD, ALS
Background:The protein encoded by this gene is a serum protein that binds insulin-like growth factors, increasing their half-life and their vascular localization. Production of the encoded protein, which contains twenty leucine-rich repeats, is stimulated by growth hormone. Defects in this gene are a cause of acid-labile subunit deficiency, which maifests itself in a delayed and slow puberty. Three transcript variants encoding two different isoforms have been found for this gene.
UniProt Protein Function:IGFALS: Involved in protein-protein interactions that result in protein complexes, receptor-ligand binding or cell adhesion.
UniProt Protein Details:

Protein type:Cell adhesion; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: nucleoplasm; extracellular space; extracellular region

Molecular Function:insulin-like growth factor binding

Biological Process: cellular protein metabolic process; signal transduction; cell adhesion

Disease: Acid-labile Subunit Deficiency

NCBI Summary:The protein encoded by this gene is a serum protein that binds insulin-like growth factors, increasing their half-life and their vascular localization. Production of the encoded protein, which contains twenty leucine-rich repeats, is stimulated by growth hormone. Defects in this gene are a cause of acid-labile subunit deficiency, which maifests itself in a delayed and slow puberty. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
UniProt Code:P35858
NCBI GenInfo Identifier:4826772
NCBI Gene ID:3483
NCBI Accession:NP_004961
UniProt Related Accession:P35858
Molecular Weight:63kDa
NCBI Full Name:insulin-like growth factor-binding protein complex acid labile subunit isoform 2
NCBI Synonym Full Names:insulin like growth factor binding protein acid labile subunit
NCBI Official Symbol:IGFALS  
NCBI Official Synonym Symbols:ALS; ACLSD  
NCBI Protein Information:insulin-like growth factor-binding protein complex acid labile subunit
UniProt Protein Name:Insulin-like growth factor-binding protein complex acid labile subunit
Protein Family:Insulin-like growth factor-binding protein complex acid labile
UniProt Gene Name:IGFALS  
UniProt Entry Name:ALS_HUMAN
Anti-IGFALS Antibody (CAB10223)Western blot analysis of extracts of various cell lines, using IGFALS antibody (CAB10223) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s.
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