Epigenetics & Nuclear Signaling Antibodies 3
Anti-IGF2BP3 Antibody (CAB4444)
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- SKU:
- CAB4444
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- IGF2BP3
- Synonyms:
- CT98
- Synonyms:
- IMP-3
- Synonyms:
- IMP3
- Synonyms:
- KOC
- Synonyms:
- KOC1
- Synonyms:
- VICKZ3
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Product Name: | IGF2BP3 Rabbit pAb |
| Product Code: | CAB4444 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | IGF2BP3, CT98, IMP-3, IMP3, KOC, KOC1, VICKZ3 |
| Applications: | WB, IHC, IF, IP |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 300-579 of human IGF2BP3 (NP_006538.2). |
| Applications: | WB, IHC, IF, IP |
| Recommended Dilutions: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 IP 1:20 - 1:50 |
| Reactivity: | Human, Mouse |
| Positive Samples: | HepG2, A-549, 293T, HeLa |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 300-579 of human IGF2BP3 (NP_006538.2). |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | KKIE QDTD TKIT ISPL QELT LYNP ERTI TVKG NVET CAKA EEEI MKKI RESY ENDI ASMN LQAH LIPG LNLN ALGL FPPT SGMP PPTS GPPS AMTP PYPQ FEQS ETET VHLF IPAL SVGA IIGK QGQH IKQL SRFA GASI KIAP AEAP DAKV RMVI ITGP PEAQ FKAQ GRIY GKIK EENF VSPK EEVK LEAH IRVP SFAA GRVI GKGG KTVN ELQN LSSA EVVV PRDQ TPDE NDQV VVKI TGHF YACQ VAQR KIQE ILTQ VKQH QQQK ALQS GPPQ SRRK |
| Gene ID: | 10643 |
| Uniprot: | O00425 |
| Cellular Location: | Cytoplasm, Nucleus |
| Calculated MW: | 21kDa/63kDa |
| Observed MW: | 70kDa |
| UniProt Protein Function: | IGF2BP3: RNA-binding protein that act as a regulator of mRNA translation and stability. Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Binds to sequences in the 3'-UTR of CD44 mRNA. Belongs to the RRM IMP/VICKZ family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Spliceosome; Translation; RNA-binding Chromosomal Location of Human Ortholog: 7p11 Cellular Component: cytoplasm; cytosol; nucleus Molecular Function:protein binding; mRNA 3'-UTR binding; RNA binding; nucleotide binding; translation regulator activity; mRNA 5'-UTR binding Biological Process: anatomical structure morphogenesis; mRNA transport; translation; negative regulation of translation; gene expression; regulation of cytokine biosynthetic process |
| NCBI Summary: | The protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5' UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during late development. The encoded protein contains several KH domains, which are important in RNA binding and are known to be involved in RNA synthesis and metabolism. A pseudogene exists on chromosome 7, and there are putative pseudogenes on other chromosomes. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O00425 |
| NCBI GenInfo Identifier: | 254763311 |
| NCBI Gene ID: | 10643 |
| NCBI Accession: | O00425.2 |
| UniProt Secondary Accession: | O00425,Q63HM0, Q6MZZ2, Q86VB1, A0A4Z5, |
| UniProt Related Accession: | O00425 |
| Molecular Weight: | 579 |
| NCBI Full Name: | Insulin-like growth factor 2 mRNA-binding protein 3 |
| NCBI Synonym Full Names: | insulin-like growth factor 2 mRNA binding protein 3 |
| NCBI Official Symbol: | IGF2BP3 |
| NCBI Official Synonym Symbols: | KOC; CT98; IMP3; KOC1; IMP-3; VICKZ3 |
| NCBI Protein Information: | insulin-like growth factor 2 mRNA-binding protein 3; VICKZ family member 3; cancer/testis antigen 98; IGF2 mRNA-binding protein 3; IGF-II mRNA-binding protein 3; KH domain containing protein overexpressed in cancer |
| UniProt Protein Name: | Insulin-like growth factor 2 mRNA-binding protein 3 |
| UniProt Synonym Protein Names: | IGF-II mRNA-binding protein 3; KH domain-containing protein overexpressed in cancer; hKOC; VICKZ family member 3 |
| Protein Family: | Insulin-like growth factor 2 mRNA-binding protein |
| UniProt Gene Name: | IGF2BP3 |
| UniProt Entry Name: | IF2B3_HUMAN |
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