Immunology Antibodies 1
Anti-IGBP1 Antibody (CAB10836)
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- SKU:
- CAB10836
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
| Antibody Name: | Anti-IGBP1 Antibody |
| Antibody SKU: | CAB10836 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-339 of human IGBP1 (NP_001542.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | A-549, Raji, Mouse spleen, Mouse thymus |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-339 of human IGBP1 (NP_001542.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MAAE DELQ LPRL PELF ETGR QLLD EVEV ATEP AGSR IVQE KVFK GLDL LEKA AEML SQLD LFSR NEDL EEIA STDL KYLL VPAF QGAL TMKQ VNPS KRLD HLQR AREH FINY LTQC HCYH VAEF ELPK TMNN SAEN HTAN SSMA YPSL VAMA SQRQ AKIQ RYKQ KKEL EHRL SAMK SAVE SGQA DDER VREY YLLH LQRW IDIS LEEI ESID QEIK ILRE RDSS REAS TSNS SRQE RPPV KPFI LTRN MAQA KVFG AGYP SLPT MTVS DWYE QHRK YGAL PDQG IAKA APEE FRKA AQQQ EEQE EKEE EDDE QTLH RARE WDDW KDTH PRGY GNRQ NMG |
| Gene ID: | 3476 |
| Uniprot: | P78318 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 39kDa |
| Observed MW: | 46kDa |
| Synonyms: | IGBP1, ALPHA-4, IBP1 |
| Background: | The proliferation and differentiation of B cells is dependent upon a B-cell antigen receptor (BCR) complex. Binding of antigens to specific B-cell receptors results in a tyrosine phosphorylation reaction through the BCR complex and leads to multiple signal transduction pathways. |
| UniProt Protein Function: | IGBP1: Associated to surface IgM-receptor; may be involved in signal transduction. May be involved in regulation of the catalytic activity of type 2A-related serine/threonine phosphatases. Associates with PP2A-alpha and PP2A-beta catalytic subunits, and with PP4 and PP6. Interacts with MID1 and MID2. Ubiquitously expressed with highest levels in heart, skeletal muscle and pancreas. Belongs to the IGBP1/TAP42 family. |
| UniProt Protein Details: | Protein type:Phosphatase, regulatory subunit; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: Xq13.1-q13.3 Cellular Component: cytosol Molecular Function:protein binding; protein phosphatase 2A binding; protein phosphatase type 2A regulator activity Biological Process: negative regulation of caspase activity; negative regulation of stress-activated MAPK cascade; negative regulation of transcription from RNA polymerase II promoter Disease: Corpus Callosum, Agenesis Of, With Mental Retardation, Ocular Coloboma, And Micrognathia |
| NCBI Summary: | The proliferation and differentiation of B cells is dependent upon a B-cell antigen receptor (BCR) complex. Binding of antigens to specific B-cell receptors results in a tyrosine phosphorylation reaction through the BCR complex and leads to multiple signal transduction pathways. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P78318 |
| NCBI GenInfo Identifier: | 14285501 |
| NCBI Gene ID: | 3476 |
| NCBI Accession: | P78318.1 |
| UniProt Secondary Accession: | P78318,Q8TAB2, |
| UniProt Related Accession: | P78318 |
| Molecular Weight: | 39,222 Da |
| NCBI Full Name: | Immunoglobulin-binding protein 1 |
| NCBI Synonym Full Names: | immunoglobulin (CD79A) binding protein 1 |
| NCBI Official Symbol: | IGBP1 |
| NCBI Official Synonym Symbols: | IBP1; ALPHA-4 |
| NCBI Protein Information: | immunoglobulin-binding protein 1 |
| UniProt Protein Name: | Immunoglobulin-binding protein 1 |
| UniProt Synonym Protein Names: | B-cell signal transduction molecule alpha 4; Protein alpha-4; CD79a-binding protein 1; Protein phosphatase 2/4/6 regulatory subunit; Renal carcinoma antigen NY-REN-16 |
| Protein Family: | Immunoglobulin-binding protein |
| UniProt Gene Name: | IGBP1 |
| UniProt Entry Name: | IGBP1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using IGBP1 antibody (CAB10836) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 40s. |
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