Immunology Antibodies 1

Anti-IFNLR1 Antibody (CAB10082)

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SKU:
CAB10082
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology

Description

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Antibody Name:Anti-IFNLR1 Antibody
Antibody SKU:CAB10082
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 21-228 of human IFNLR1 (NP_734464.1).
Application:WB
Recommended Dilution:WB 1:1000 - 1:4000
Reactivity:Human, Mouse, Rat
Positive Samples:HT-29, Jurkat, MCF7, Mouse lung, Mouse heart, Mouse small intestine, Rat lung, Rat heart
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 21-228 of human IFNLR1 (NP_734464.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:RPRL APPQ NVTL LSQN FSVY LTWL PGLG NPQD VTYF VAYQ SSPT RRRW REVE ECAG TKEL LCSM MCLK KQDL YNKF KGRV RTVS PSSK SPWV ESEY LDYL FEVE PAPP VLVL TQTE EILS ANAT YQLP PCMP PLDL KYEV AFWK EGAG NKTL FPVT PHGQ PVQI TLQP AASE HHCL SART IYTF SVPK YSKF SKPT CFLL EVPE ANWA
Gene ID:163702
Uniprot:Q8IU57
Cellular Location:Membrane, Single-pass type I membrane protein
Calculated MW:23kDa/27kDa/54kDa/57kDa
Observed MW:53kDa
Synonyms:IFNLR1, CRF2/12, IFNLR, IL-28R1, IL28RA, LICR2
Background:The protein encoded by this gene belongs to the class II cytokine receptor family. This protein forms a receptor complex with interleukine 10 receptor, beta (IL10RB). The receptor complex has been shown to interact with three closely related cytokines, including interleukin 28A (IL28A), interleukin 28B (IL28B), and interleukin 29 (IL29). The expression of all three cytokines can be induced by viral infection. The cells overexpressing this protein have been found to have enhanced responses to IL28A and IL29, but decreased response to IL28B. Three alternatively spliced transcript variants encoding distinct isoforms have been reported.
UniProt Protein Function:IL28RA: The IL28RA/IL10RB dimer is a receptor for IL28A, IL28B and IL29. The ligand/receptor complex seems to signal through the Jak-STAT pathway. Belongs to the type II cytokine receptor family. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral

Chromosomal Location of Human Ortholog: 1p36.11

Cellular Component: integral to membrane; interleukin-28 receptor complex

Molecular Function:hematopoietin/interferon-class (D200-domain) cytokine receptor activity; protein binding

Biological Process: negative regulation of cell proliferation; mucosal immune response; cytokine and chemokine mediated signaling pathway; regulation of defense response to virus by host; defense response to virus

NCBI Summary:The protein encoded by this gene belongs to the class II cytokine receptor family. This protein forms a receptor complex with interleukine 10 receptor, beta (IL10RB). The receptor complex has been shown to interact with three closely related cytokines, including interleukin 28A (IL28A), interleukin 28B (IL28B), and interleukin 29 (IL29). The expression of all three cytokines can be induced by viral infection. The cells overexpressing this protein have been found to have enhanced responses to IL28A and IL29, but decreased response to IL28B. Three alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
UniProt Code:Q8IU57
NCBI GenInfo Identifier:55976528
NCBI Gene ID:163702
NCBI Accession:Q8IU57.1
UniProt Related Accession:Q8IU57
Molecular Weight:Observed MW: 57kDa
NCBI Full Name:Interferon lambda receptor 1
NCBI Synonym Full Names:interferon lambda receptor 1
NCBI Official Symbol:IFNLR1  
NCBI Official Synonym Symbols:IFNLR; LICR2; IL28RA; CRF2/12; IL-28R1  
NCBI Protein Information:interferon lambda receptor 1
UniProt Protein Name:Interferon lambda receptor 1
UniProt Synonym Protein Names:Cytokine receptor class-II member 12; Cytokine receptor family 2 member 12; CRF2-12; Interleukin-28 receptor subunit alpha; IL-28 receptor subunit alpha; IL-28R-alpha; IL-28RA; Likely interleukin or cytokine receptor 2
UniProt Gene Name:IFNLR1  
UniProt Entry Name:INLR1_HUMAN
Anti-IFNLR1 Antibody (CAB10082)Western blot analysis of extracts of various cell lines, using IFNLR1 antibody (CAB10082) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.
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