Cell Biology Antibodies 4

Anti-IFNGR2 Antibody (CAB14221)

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SKU:
CAB14221
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-IFNGR2 Antibody
Antibody SKU:CAB14221
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 200 to the C-terminus of human IFNGR2 (NP_005525.2).
Application:WB IHC IF
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:A-549, HepG2, Rat heart
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 200 to the C-terminus of human IFNGR2 (NP_005525.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:DNLK PSRV YCLQ VQAQ LLWN KSNI FRVG HLSN ISCY ETMA DAST ELQQ VILI SVGT FSLL SVLA GACF FLVL KYRG LIKY WFHT PPSI PLQI EEYL KDPT QPIL EALD KDSS PKDD VWDS VSII SFPE KEQE DVLQ TL
Gene ID:3460
Uniprot:P38484
Cellular Location:Membrane, Single-pass type I membrane protein
Calculated MW:37kDa
Observed MW:38kDa
Synonyms:IFNGR2, AF-1, IFGR2, IFNGT1, IMD28
Background:This gene (IFNGR2) encodes the non-ligand-binding beta chain of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. Defects in IFNGR2 are a cause of mendelian susceptibility to mycobacterial disease (MSMD), also known as familial disseminated atypical mycobacterial infection. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance.
UniProt Protein Function:IFNGR2: Part of the receptor for interferon gamma. Required for signal transduction. This accessory factor is an integral part of the IFN-gamma signal transduction pathway and is likely to interact with GAF, JAK1, and/or JAK2. Defects in IFNGR2 are a cause of mendelian susceptibility to mycobacterial disease (MSMD); also known as familial disseminated atypical mycobacterial infection. This rare condition confers predisposition to illness caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine and environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to mycobacterial infections, with the exception of Salmonella which infects less than 50% of these individuals. The pathogenic mechanism underlying MSMD is the impairment of interferon-gamma mediated immunity, whose severity determines the clinical outcome. Some patients die of overwhelming mycobacterial disease with lepromatous-like lesions in early childhood, whereas others develop, later in life, disseminated but curable infections with tuberculoid granulomas. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance. Belongs to the type II cytokine receptor family.
UniProt Protein Details:

Protein type:Membrane protein, integral

Chromosomal Location of Human Ortholog: 21q22.11

Cellular Component: integral to plasma membrane; endoplasmic reticulum; integral to membrane; plasma membrane

Molecular Function:hematopoietin/interferon-class (D200-domain) cytokine receptor activity; interferon-gamma receptor activity

Biological Process: cell surface receptor linked signal transduction; response to virus; cytokine and chemokine mediated signaling pathway

Disease: Immunodeficiency 28

NCBI Summary:This gene (IFNGR2) encodes the non-ligand-binding beta chain of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. Defects in IFNGR2 are a cause of mendelian susceptibility to mycobacterial disease (MSMD), also known as familial disseminated atypical mycobacterial infection. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance. [provided by RefSeq, Jul 2008]
UniProt Code:P38484
NCBI GenInfo Identifier:145559548
NCBI Gene ID:3460
NCBI Accession:P38484.2
UniProt Secondary Accession:P38484,Q9BTL5,
UniProt Related Accession:P38484
Molecular Weight:337
NCBI Full Name:Interferon gamma receptor 2
NCBI Synonym Full Names:interferon gamma receptor 2 (interferon gamma transducer 1)
NCBI Official Symbol:IFNGR2  
NCBI Official Synonym Symbols:AF-1; IFGR2; IMD28; IFNGT1  
NCBI Protein Information:interferon gamma receptor 2; IFN-gamma-R2; IFN-gamma receptor 2; interferon gamma transducer 1; interferon gamma receptor beta chain; interferon gamma receptor accessory factor 1; interferon gamma receptor accessory factor-1
UniProt Protein Name:Interferon gamma receptor 2
UniProt Synonym Protein Names:Interferon gamma receptor accessory factor 1; AF-1; Interferon gamma transducer 1
Protein Family:Interferon gamma receptor
UniProt Gene Name:IFNGR2  
UniProt Entry Name:INGR2_HUMAN
Anti-IFNGR2 Antibody (CAB14221)Western blot analysis of extracts of various cell lines, using IFNGR2 Rabbit pAb (CAB14221) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s.
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