Cell Biology Antibodies 9
Anti-IFNGR1 Antibody (CAB5748)
(No reviews yet)
Write a Review
- SKU:
- CAB5748
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-IFNGR1 Antibody |
| Antibody SKU: | CAB5748 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 270-489 of human IFNGR1 (NP_000407.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HL-60, THP-1, HeLa, SW620, Mouse lung, Mouse spleen, Mouse heart, Mouse skeletal muscle |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 270-489 of human IFNGR1 (NP_000407.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | IKKI NPLK EKSI ILPK SLIS VVRS ATLE TKPE SKYV SLIT SYQP FSLE KEVV CEEP LSPA TVPG MHTE DNPG KVEH TEEL SSIT EVVT TEEN IPDV VPGS HLTP IERE SSSP LSSN QSEP GSIA LNSY HSRN CSES DHSR NGFD TDSS CLES HSSL SDSE FPPN NKGE IKTE GQEL ITVI KAPT SFGY DKPH VLVD LLVD DSGK ESLI GYRP TEDS KEFS |
| Gene ID: | 3459 |
| Uniprot: | P15260 |
| Cellular Location: | Membrane, Single-pass type I membrane protein |
| Calculated MW: | 21kDa/54kDa |
| Observed MW: | 70kDa |
| Synonyms: | IFNGR1, CD119, IFNGR, IMD27A, IMD27B |
| Background: | This gene (IFNGR1) encodes the ligand-binding chain (alpha) of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. A genetic variation in IFNGR1 is associated with susceptibility to Helicobacter pylori infection. In addition, defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease, also known as familial disseminated atypical mycobacterial infection. |
| UniProt Protein Function: | IFNGR1: Receptor for interferon gamma. Two receptors bind one interferon gamma dimer. Defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease (MSMD); also known as familial disseminated atypical mycobacterial infection. This rare condition confers predisposition to illness caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine and environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to mycobacterial infections, with the exception of Salmonella which infects less than 50% of these individuals. The pathogenic mechanism underlying MSMD is the impairment of interferon-gamma mediated immunity whose severity determines the clinical outcome. Some patients die of overwhelming mycobacterial disease with lepromatous-like lesions in early childhood, whereas others develop, later in life, disseminated but curable infections with tuberculoid granulomas. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance. Belongs to the type II cytokine receptor family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Receptor, cytokine Chromosomal Location of Human Ortholog: 6q23.3 Cellular Component: integral to plasma membrane; endoplasmic reticulum; dendrite; postsynaptic density; plasma membrane; integral to membrane; vesicle Molecular Function:hematopoietin/interferon-class (D200-domain) cytokine receptor activity; protein binding; interferon-gamma receptor activity; cytokine binding Biological Process: cytokine and chemokine mediated signaling pathway; response to virus; signal transduction Disease: Helicobacter Pylori Infection, Susceptibility To; Immunodeficiency 27b; Immunodeficiency 27a; Mycobacterium Tuberculosis, Susceptibility To; Hepatitis B Virus, Susceptibility To |
| NCBI Summary: | This gene (IFNGR1) encodes the ligand-binding chain (alpha) of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. A genetic variation in IFNGR1 is associated with susceptibility to Helicobacter pylori infection. In addition, defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease, also known as familial disseminated atypical mycobacterial infection. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P15260 |
| NCBI GenInfo Identifier: | 124474 |
| NCBI Gene ID: | 3459 |
| NCBI Accession: | P15260.1 |
| UniProt Secondary Accession: | P15260,Q53Y96, B4DFT7, E1P587, |
| UniProt Related Accession: | P15260 |
| Molecular Weight: | Calculated: 21kDa/54kDaObserved: 70kDa |
| NCBI Full Name: | Interferon gamma receptor 1 |
| NCBI Synonym Full Names: | interferon gamma receptor 1 |
| NCBI Official Symbol: | IFNGR1 |
| NCBI Official Synonym Symbols: | CD119; IFNGR; IMD27A; IMD27B |
| NCBI Protein Information: | interferon gamma receptor 1; CDw119; AVP, type 2; IFN-gamma-R1; CD119 antigen; IFN-gamma receptor 1; antiviral protein, type 2; immune interferon receptor 1; interferon-gamma receptor alpha chain |
| UniProt Protein Name: | Interferon gamma receptor 1 |
| UniProt Synonym Protein Names: | CDw119; CD_antigen: CD119 |
| Protein Family: | Interferon gamma receptor |
| UniProt Gene Name: | IFNGR1 |
| UniProt Entry Name: | INGR1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using IFNGR1 antibody (CAB5748) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
 | Immunohistochemistry of paraffin-embedded mouse spleen using IFNGR1 Rabbit pAb (CAB5748) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded rat spleen using IFNGR1 Rabbit pAb (CAB5748) at dilution of 1:100 (40x lens). |
View AllClose
Related Products
IFNGR1 Monoclonal Antibody
OverviewProduct Name:IFNGR1 Monoclonal AntibodyProduct Code:CAB21912Reactivity:Human, Mouse, RatApplications:Western blotting, Im
Human IFNGR1 Recombinant Protein (RPPB0408)
Cytokines Recombinant Proteins
system_update_altDatasheetsystem_update_altMSDS
Mouse IFNGR1 Recombinant Protein (RPES1391)
system_update_altDatasheetMouse IFNGR1 Recombinant Protein The tetrameric receptor complex for IFN? consists of two subunits, IFNGR1 (IFN? R?) and IFNGR2 (IFN? Rβ), through which the dimeric
Human IFNGR1 Recombinant Protein (RPES4121)
system_update_altDatasheetHuman IFNGR1 Recombinant Protein Interferon gamma receptor 1(IFNGR1) encoded by the IFNGR1 gene, is a single-pass type 1 membrane protein which belongs to the type II cy