Immunology Antibodies 2
Anti-IFNB1 Antibody (CAB1575)
- SKU:
- CAB1575
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
| Antibody Name: | Anti-IFNB1 Antibody |
| Antibody SKU: | CAB1575 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 30-187 of human IFNB1 (NP_002167.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | MCF7, THP-1 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 30-187 of human IFNB1 (NP_002167.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LQRS SNFQ CQKL LWQL NGRL EYCL KDRM NFDI PEEI KQLQ QFQK EDAA LTIY EMLQ NIFA IFRQ DSSS TGWN ETIV ENLL ANVY HQIN HLKT VLEE KLEK EDFT RGKL MSSL HLKR YYGR ILHY LKAK EYSH CAWT IVRV EILR NFYF INRL TGYL RN |
| Gene ID: | 3456 |
| Uniprot: | P01574 |
| Cellular Location: | Secreted |
| Calculated MW: | 22kDa |
| Observed MW: | 22kDa |
| Synonyms: | IFNB1, IFB, IFF, IFN-beta, IFNB |
| Background: | This gene encodes a cytokine that belongs to the interferon family of signaling proteins, which are released as part of the innate immune response to pathogens. The protein encoded by this gene belongs to the type I class of interferons, which are important for defense against viral infections. In addition, type I interferons are involved in cell differentiation and anti-tumor defenses. Following secretion in response to a pathogen, type I interferons bind a homologous receptor complex and induce transcription of genes such as those encoding inflammatory cytokines and chemokines. Overactivation of type I interferon secretion is linked to autoimmune diseases. Mice deficient for this gene display several phenotypes including defects in B cell maturation and increased susceptibility to viral infection. |
| UniProt Protein Function: | IFNB1: Has antiviral, antibacterial and anticancer activities. Belongs to the alpha/beta interferon family. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 9p21 Cellular Component: extracellular space; extracellular region Molecular Function:interferon-alpha/beta receptor binding; cytokine activity Biological Process: B cell proliferation; adaptive immune response; cytokine and chemokine mediated signaling pathway; response to virus; regulation of MHC class I biosynthetic process; natural killer cell activation; negative regulation of T cell differentiation; humoral immune response; T cell activation during immune response; response to exogenous dsRNA; cell surface receptor linked signal transduction; negative regulation of viral genome replication; B cell differentiation; positive regulation of innate immune response; defense response to bacterium; natural killer cell activation during immune response; innate immune response; positive regulation of transcription from RNA polymerase II promoter; blood coagulation; defense response to virus; B cell activation during immune response; positive regulation of peptidyl-serine phosphorylation of STAT protein |
| UniProt Code: | P01574 |
| NCBI GenInfo Identifier: | 124469 |
| NCBI Gene ID: | 3456 |
| NCBI Accession: | P01574.1 |
| UniProt Secondary Accession: | P01574,Q5VWC9, |
| UniProt Related Accession: | P01574 |
| Molecular Weight: | 187 |
| NCBI Full Name: | Interferon beta |
| NCBI Synonym Full Names: | interferon, beta 1, fibroblast |
| NCBI Official Symbol: | IFNB1 |
| NCBI Official Synonym Symbols: | IFB; IFF; IFNB |
| NCBI Protein Information: | interferon beta; IFN-beta; fibroblast interferon |
| UniProt Protein Name: | Interferon beta |
| UniProt Synonym Protein Names: | Fibroblast interferon |
| Protein Family: | Interferon |
| UniProt Gene Name: | IFNB1 |
| UniProt Entry Name: | IFNB_HUMAN |
 | Western blot analysis of extracts of various cell lines, using IFNB1 antibody (CAB1575) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
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