Cell Biology Antibodies 7
Anti-IFNAR2 Antibody (CAB1769)
(No reviews yet)
Write a Review
- SKU:
- CAB1769
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-IFNAR2 Antibody |
| Antibody SKU: | CAB1769 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 27-243 of human IFNAR2 (NP_997467.1). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | MCF7, Raji, HepG2, THP-1, SW480, A-549, HeLa, Mouse liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 27-243 of human IFNAR2 (NP_997467.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | ISYD SPDY TDES CTFK ISLR NFRS ILSW ELKN HSIV PTHY TLLY TIMS KPED LKVV KNCA NTTR SFCD LTDE WRST HEAY VTVL EGFS GNTT LFSC SHNF WLAI DMSF EPPE FEIV GFTN HINV MVKF PSIV EEEL QFDL SLVI EEQS EGIV KKHK PEIK GNMS GNFT YIID KLIP NTNY CVSV YLEH SDEQ AVIK SPLK CTLL PPGQ ESES AESA K |
| Gene ID: | 3455 |
| Uniprot: | P48551 |
| Cellular Location: | Membrane, Secreted, Single-pass type I membrane protein |
| Calculated MW: | 27kDa/37kDa/57kDa |
| Observed MW: | 58kDa |
| Synonyms: | IFNAR2, IFN-R, IFN-alpha-REC, IFNABR, IFNARB, IMD45 |
| Background: | The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. Multiple transcript variants encoding at least two different isoforms have been found for this gene. |
| UniProt Protein Function: | IFNAR2: Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation. Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1. Isoform 3 is a potent inhibitor of type I IFN receptor activity. Belongs to the type II cytokine receptor family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Receptor, cytokine; Membrane protein, integral Chromosomal Location of Human Ortholog: 21q22.11 Cellular Component: extracellular space; integral to plasma membrane; plasma membrane; extracellular region Molecular Function:protein binding; interferon-alpha/beta receptor activity; interferon-alpha/beta binding; protein kinase binding Biological Process: regulation of transcription from RNA polymerase II promoter; cell proliferation; cell surface receptor linked signal transduction; cytokine and chemokine mediated signaling pathway; response to virus; JAK-STAT cascade Disease: Hepatitis B Virus, Susceptibility To |
| NCBI Summary: | The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. Multiple transcript variants encoding at least two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P48551 |
| NCBI GenInfo Identifier: | 1352466 |
| NCBI Gene ID: | 3455 |
| NCBI Accession: | P48551.1 |
| UniProt Secondary Accession: | P48551,Q15467, Q6FHD7, A8KAJ4, D3DSE8, D3DSE9, |
| UniProt Related Accession: | P48551 |
| Molecular Weight: | 515 |
| NCBI Full Name: | Interferon alpha/beta receptor 2 |
| NCBI Synonym Full Names: | interferon (alpha, beta and omega) receptor 2 |
| NCBI Official Symbol: | IFNAR2 |
| NCBI Official Synonym Symbols: | IFN-R; IFNABR; IFNARB; IFN-alpha-REC |
| NCBI Protein Information: | interferon alpha/beta receptor 2; IFN-R-2; IFN-alpha/beta receptor 2; type I interferon receptor 2; interferon alpha binding protein; human interferon alpha/beta receptor; interferon-alpha/beta receptor beta chain |
| UniProt Protein Name: | Interferon alpha/beta receptor 2 |
| UniProt Synonym Protein Names: | Interferon alpha binding protein; Type I interferon receptor 2 |
| UniProt Gene Name: | IFNAR2 |
| UniProt Entry Name: | INAR2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using IFNAR2 antibody (CAB1769) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
 | Immunohistochemistry of paraffin-embedded human colon carcinoma using IFNAR2 antibody (CAB1769) at dilution of 1:100 (40x lens). |
 | Immunofluorescence analysis of U2OS cells using IFNAR2 antibody (CAB1769). Blue: DAPI for nuclear staining. |
View AllClose
Related Products
IFNAR2 Polyclonal Antibody (CAB21462)
OverviewProduct Name:IFNAR2 Polyclonal AntibodyProduct Code:CAB21462Reactivity:Human, Mouse, RatApplications:Western blotting
IFNAR2 Polyclonal Antibody (CAB21759)
IFNAR2 Polyclonal Antibody (CAB21759)The product page for this antibody is being prepared. If you have a question please don't hesitate to get in touch!
