Cell Biology Antibodies 14
Anti-IFNAR2 Antibody (CAB16883)
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- SKU:
- CAB16883
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-IFNAR2 Antibody |
| Antibody SKU: | CAB16883 |
| Antibody Size: | 20uL, 50 uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human IFNAR2. |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: |
| Immunogen: | Recombinant protein of human IFNAR2. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 3455 |
| Uniprot: | P48551 |
| Cellular Location: | |
| Calculated MW: | |
| Observed MW: | Refer to figures |
| Synonyms: | IFNAR2, IFN-R, IFN-alpha-REC, IFNABR, IFNARB, IMD45 |
| Background: | The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. Multiple transcript variants encoding at least two different isoforms have been found for this gene. |
| UniProt Protein Function: | IFNAR2: Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation. Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1. Isoform 3 is a potent inhibitor of type I IFN receptor activity. Belongs to the type II cytokine receptor family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Receptor, cytokine; Membrane protein, integral Chromosomal Location of Human Ortholog: 21q22.11 Cellular Component: extracellular space; integral to plasma membrane; plasma membrane; extracellular region Molecular Function:protein binding; interferon-alpha/beta receptor activity; interferon-alpha/beta binding; protein kinase binding Biological Process: regulation of transcription from RNA polymerase II promoter; cell proliferation; cell surface receptor linked signal transduction; cytokine and chemokine mediated signaling pathway; response to virus; JAK-STAT cascade Disease: Hepatitis B Virus, Susceptibility To |
| NCBI Summary: | The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. Multiple transcript variants encoding at least two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P48551 |
| NCBI GenInfo Identifier: | 1352466 |
| NCBI Gene ID: | 3455 |
| NCBI Accession: | P48551.1 |
| UniProt Secondary Accession: | P48551,Q15467, Q6FHD7, A8KAJ4, D3DSE8, D3DSE9, |
| UniProt Related Accession: | P48551 |
| Molecular Weight: | 515 |
| NCBI Full Name: | Interferon alpha/beta receptor 2 |
| NCBI Synonym Full Names: | interferon (alpha, beta and omega) receptor 2 |
| NCBI Official Symbol: | IFNAR2 |
| NCBI Official Synonym Symbols: | IFN-R; IFNABR; IFNARB; IFN-alpha-REC |
| NCBI Protein Information: | interferon alpha/beta receptor 2; IFN-R-2; IFN-alpha/beta receptor 2; type I interferon receptor 2; interferon alpha binding protein; human interferon alpha/beta receptor; interferon-alpha/beta receptor beta chain |
| UniProt Protein Name: | Interferon alpha/beta receptor 2 |
| UniProt Synonym Protein Names: | Interferon alpha binding protein; Type I interferon receptor 2 |
| UniProt Gene Name: | IFNAR2 |
| UniProt Entry Name: | INAR2_HUMAN |
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