Cell Biology Antibodies 7
Anti-IFNAR1 Antibody (CAB1715)
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- SKU:
- CAB1715
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-IFNAR1 Antibody |
| Antibody SKU: | CAB1715 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 28-290 of human IFNAR1 (NP_000620.2). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | SW480, K562 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 28-290 of human IFNAR1 (NP_000620.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | KNLK SPQK VEVD IIDD NFIL RWNR SDES VGNV TFSF DYQK TGMD NWIK LSGC QNIT STKC NFSS LKLN VYEE IKLR IRAE KENT SSWY EVDS FTPF RKAQ IGPP EVHL EAED KAIV IHIS PGTK DSVM WALD GLSF TYSL VIWK NSSG VEER IENI YSRH KIYK LSPE TTYC LKVK AALL TSWK IGVY SPVH CIKT TVEN ELPP PENI EVSV QNQN YVLK WDYT YANM TFQV QWLH AFLK RNPG NHLY KWKQ IPDC ENVK TTQ |
| Gene ID: | 3454 |
| Uniprot: | P17181 |
| Cellular Location: | Membrane, Single-pass type I membrane protein |
| Calculated MW: | 49kDa/56kDa/63kDa |
| Observed MW: | 70kDa |
| Synonyms: | IFNAR1, AVP, IFN-alpha-REC, IFNAR, IFNBR, IFRC |
| Background: | The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor. |
| UniProt Protein Function: | IFNAR1: receptor for interferons alpha and beta. Belongs to the type II cytokine family of receptors. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta-subunits themselves. Tyk2 tyrosine kinase is essential for stable cell surface expression of IFNAR1. Present in all tissues and even on the surface of most IFN-resistant cells. |
| UniProt Protein Details: | Protein type:Receptor, cytokine; Membrane protein, integral Chromosomal Location of Human Ortholog: 21q22.11 Cellular Component: integral to plasma membrane; integral to membrane; plasma membrane Molecular Function:protein binding; interferon receptor activity; interferon-alpha/beta receptor activity Biological Process: positive regulation of interferon-gamma production; cell surface receptor linked signal transduction; T cell activation; cytokine and chemokine mediated signaling pathway; response to virus; positive regulation of interleukin-1 beta secretion; interferon type I biosynthetic process; JAK-STAT cascade; defense response to virus |
| NCBI Summary: | The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P17181 |
| NCBI GenInfo Identifier: | 90110827 |
| NCBI Gene ID: | 3454 |
| NCBI Accession: | P17181.3 |
| UniProt Secondary Accession: | P17181,Q53GW9, Q53H11, Q6PKD7, Q7M4L2, Q8WTZ2, B2R6L9 B4DNT3, D3DSF0, |
| UniProt Related Accession: | P17181 |
| Molecular Weight: | Calculated MW: 49kDa/56kDa/63kDaObserved MW: 70kDa |
| NCBI Full Name: | Interferon alpha/beta receptor 1 |
| NCBI Synonym Full Names: | interferon (alpha, beta and omega) receptor 1 |
| NCBI Official Symbol: | IFNAR1 |
| NCBI Official Synonym Symbols: | AVP; IFRC; IFNAR; IFNBR; IFN-alpha-REC |
| NCBI Protein Information: | interferon alpha/beta receptor 1; CRF2-1; IFN-R-1; IFN-alpha/beta receptor 1; interferon-beta receptor 1; beta-type antiviral protein; alpha-type antiviral protein; type I interferon receptor 1; cytokine receptor class-II member 1; cytokine receptor family 2 member 1; interferon-alpha/beta receptor alpha chain |
| UniProt Protein Name: | Interferon alpha/beta receptor 1 |
| UniProt Synonym Protein Names: | Cytokine receptor class-II member 1; Cytokine receptor family 2 member 1; CRF2-1; Type I interferon receptor 1 |
| Protein Family: | Interferon alpha/beta receptor |
| UniProt Gene Name: | IFNAR1 |
| UniProt Entry Name: | INAR1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using IFNAR1 antibody (CAB1715) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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