Immunology Antibodies 1

Anti-IFITM2 Antibody (CAB15133)

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SKU:
CAB15133
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology

Description

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Antibody Name:Anti-IFITM2 Antibody
Antibody SKU:CAB15133
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human IFITM2 (NP_006426.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:HeLa
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human IFITM2 (NP_006426.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MNHI VQTF SPVN SGQP PNYE MLKE EQEV AMLG VPHN PAPP MSTV IHIR SETS VPDH VVWS LFNT LFMN TCCL GFIA FAYS VKSR DRKM VGDV TGAQ AYAS
Gene ID:10581
Uniprot:Q01629
Cellular Location:Cell membrane, Single-pass membrane protein
Calculated MW:14kDa
Observed MW:17kDa
Synonyms:IFITM2, 1-8D, DSPA2c
Background:
UniProt Protein Function:IFITM2: IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and vesicular stomatitis virus (VSV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry, SARS-CoV S protein-mediated viral entry and VSV G protein- mediated viral entry. Induces cell cycle arrest and mediates apoptosis by caspase activation and in p53-independent manner. Belongs to the CD225/Dispanin family.
UniProt Protein Details:

Protein type:Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11p15.5

Cellular Component: integral to membrane; plasma membrane

Biological Process: cytokine and chemokine mediated signaling pathway; defense response to virus; immune response; negative regulation of viral genome replication; negative regulation of virion penetration into host cell; response to virus

UniProt Code:Q01629
NCBI GenInfo Identifier:151101191
NCBI Gene ID:10581
NCBI Accession:NP_006426.2
UniProt Secondary Accession:Q01629,Q6FH82, Q96DA8,
UniProt Related Accession:Q01629
Molecular Weight:14,632 Da
NCBI Full Name:interferon-induced transmembrane protein 2
NCBI Synonym Full Names:interferon induced transmembrane protein 2
NCBI Official Symbol:IFITM2  
NCBI Official Synonym Symbols:1-8D; DSPA2c  
NCBI Protein Information:interferon-induced transmembrane protein 2
UniProt Protein Name:Interferon-induced transmembrane protein 2
UniProt Synonym Protein Names:Dispanin subfamily A member 2c; DSPA2c; Interferon-inducible protein 1-8D
UniProt Gene Name:IFITM2  
UniProt Entry Name:IFM2_HUMAN
Anti-IFITM2 Antibody (CAB15133)Western blot analysis of extracts of HeLa cells, using IFITM2 antibody (CAB15133) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s.
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