Immunology Antibodies 2

Anti-IFITM1 Antibody (CAB4228)

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SKU:
CAB4228
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Immunology

Description

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Antibody Name:Anti-IFITM1 Antibody
Antibody SKU:CAB4228
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 50 to the C-terminus of human IFITM1 (NP_003632.3).
Application:WB IHC
Recommended Dilution:WB 1:200 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse
Positive Samples:K-562
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 50 to the C-terminus of human IFITM1 (NP_003632.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:CCLG FIAF AYSV KSRD RKMV GDVT GAQA YAST AKCL NIWA LILG ILMT IGFI LLLV FGSV TVYH IMLQ IIQE KRGY
Gene ID:8519
Uniprot:P13164
Cellular Location:Cell membrane, Single-pass membrane protein
Calculated MW:13kDa
Observed MW:17kDa
Synonyms:IFITM1, 9-27, CD225, DSPA2a, IFI17, LEU13
Background:
UniProt Protein Function:IFITM1: IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV). Can inhibit: influenza virus hemagglutinin protein- mediated viral entry, MARV and EBOV GP1,2-mediated viral entry and SARS-CoV S protein-mediated viral entry. Also implicated in cell adhesion and control of cell growth and migration. Plays a key role in the antiproliferative action of IFN-gamma either by inhibiting the ERK activation or by arresting cell growth in G1 phase in a p53-dependent manner. Acts as a positive regulator of osteoblast differentiation. Belongs to the CD225/Dispanin family.
UniProt Protein Details:

Protein type:Cell cycle regulation; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 11p15.5

Cellular Component: membrane; integral to membrane; plasma membrane

Molecular Function:protein binding; receptor signaling protein activity

Biological Process: positive regulation of osteoblast differentiation; negative regulation of cell proliferation; regulation of immune response; ossification; cell surface receptor linked signal transduction; negative regulation of viral genome replication; negative regulation of virion penetration into host cell; cytokine and chemokine mediated signaling pathway; response to virus; defense response to virus; negative regulation of cell migration

UniProt Code:P13164
NCBI GenInfo Identifier:215274118
NCBI Gene ID:8519
NCBI Accession:P13164.3
UniProt Secondary Accession:P13164,Q15322, Q53XZ0,
UniProt Related Accession:P13164,AAB25699
Molecular Weight:125
NCBI Full Name:Interferon-induced transmembrane protein 1
NCBI Synonym Full Names:interferon induced transmembrane protein 1
NCBI Official Symbol:IFITM1  
NCBI Official Synonym Symbols:9-27; CD225; IFI17; LEU13; DSPA2a  
NCBI Protein Information:interferon-induced transmembrane protein 1; leu-13 antigen; interferon-induced protein 17; dispanin subfamily A member 2a; interferon-inducible protein 9-27
UniProt Protein Name:Interferon-induced transmembrane protein 1
UniProt Synonym Protein Names:Dispanin subfamily A member 2a; DSPA2a; Interferon-induced protein 17; Interferon-inducible protein 9-27; Leu-13 antigen; CD_antigen: CD225
UniProt Gene Name:IFITM1  
UniProt Entry Name:IFM1_HUMAN
Anti-IFITM1 Antibody (CAB4228)Western blot analysis of extracts of K-562 cells, using IFITM1 antibody (CAB4228) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
Anti-IFITM1 Antibody (CAB4228)Immunohistochemistry of paraffin-embedded mouse liver using IFITM1 antibody (CAB4228) at dilution of 1:100 (40x lens).
Anti-IFITM1 Antibody (CAB4228)Immunohistochemistry of paraffin-embedded mouse spleen using IFITM1 antibody (CAB4228) at dilution of 1:100 (40x lens).
Anti-IFITM1 Antibody (CAB4228)Immunohistochemistry of paraffin-embedded mouse kidney using IFITM1 antibody (CAB4228) at dilution of 1:100 (40x lens).
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