Immunology Antibodies 1

Anti-IFIT2 Antibody (CAB13760)

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SKU:
CAB13760
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology

Description

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Antibody Name:Anti-IFIT2 Antibody
Antibody SKU:CAB13760
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 273-472 of human IFIT2 (NP_001538.4).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:A-431, HepG2
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 273-472 of human IFIT2 (NP_001538.4).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:ALEY IPNN AYLH CQIG CCYR AKVF QVMN LREN GMYG KRKL LELI GHAV AHLK KADE ANDN LFRV CSIL ASLH ALAD QYED AEYY FQKE FSKE LTPV AKQL LHLR YGNF QLYQ MKCE DKAI HHFI EGVK INQK SREK EKMK DKLQ KIAK MRLS KNGA DSEA LHVL AFLQ ELNE KMQQ ADED SERG LESG SLIP SASS WNGE
Gene ID:3433
Uniprot:P09913
Cellular Location:Cytoplasm, Endoplasmic reticulum
Calculated MW:54kDa
Observed MW:50kDa
Synonyms:IFIT2, G10P2, GARG-39, IFI-54, IFI-54K, IFI54, IFIT-2, ISG-54 K, ISG-54K, ISG54, P54, cig42
Background:
UniProt Protein Function:IFIT2: IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2'-O-methylation of the 5' cap. The ribose 2'-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O- methylation (cap snatching mechanism). Can promote apoptosis. Belongs to the IFIT family.
UniProt Protein Details:

Protein type:Unknown function

Chromosomal Location of Human Ortholog: 10q23.31

Cellular Component: endoplasmic reticulum; cytoplasm; cytosol

Molecular Function:protein binding

Biological Process: apoptotic mitochondrial changes; positive regulation of apoptosis; cytokine and chemokine mediated signaling pathway; response to virus; negative regulation of protein binding; defense response to virus

UniProt Code:P09913
NCBI GenInfo Identifier:153082755
NCBI Gene ID:3433
NCBI Accession:NP_001538.4
UniProt Secondary Accession:P09913,Q5T767,
UniProt Related Accession:P09913
Molecular Weight:54,632 Da
NCBI Full Name:interferon-induced protein with tetratricopeptide repeats 2
NCBI Synonym Full Names:interferon-induced protein with tetratricopeptide repeats 2
NCBI Official Symbol:IFIT2  
NCBI Official Synonym Symbols:P54; G10P2; IFI54; ISG54; cig42; IFI-54; IFIT-2; GARG-39; IFI-54K; ISG-54K; ISG-54 K  
NCBI Protein Information:interferon-induced protein with tetratricopeptide repeats 2; interferon-induced protein 54; interferon-induced 54 kDa protein; Interferon, alpha-inducible protein (MW 54kD)
UniProt Protein Name:Interferon-induced protein with tetratricopeptide repeats 2
UniProt Synonym Protein Names:ISG-54 K; Interferon-induced 54 kDa protein; IFI-54K; P54
Protein Family:Interferon-induced protein with tetratricopeptide repeats
UniProt Gene Name:IFIT2  
UniProt Entry Name:IFIT2_HUMAN
Anti-IFIT2 Antibody (CAB13760)Western blot analysis of extracts of various cell lines, using IFIT2 antibody (CAB13760) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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