Cell Biology Antibodies 14
Anti-IFI30 Antibody (CAB12995)
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- SKU:
- CAB12995
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-IFI30 Antibody |
| Antibody SKU: | CAB12995 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human IFI30 (NP_006323.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | A-431, Raji |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human IFI30 (NP_006323.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MTLS PLLL FLPP LLLL LDVP TAAV QASP LQAL DFFG NGPP VNYK TGNL YLRG PLKK SNAP LVNV TLYY EALC GGCR AFLI RELF PTWL LVME ILNV TLVP YGNA QEQN VSGR WEFK CQHG EEEC KFNK VEAC VLDE LDME LAFL TIVC MEEF EDME RSLP LCLQ LYAP GLSP DTIM ECAM GDRG MQLM HANA QRTD ALQP PHEY VPWV TVNG KPLE DQTQ LLTL VCQL YQGK KPDV CPSS TSSL RSVC FK |
| Gene ID: | 10437 |
| Uniprot: | P13284 |
| Cellular Location: | Lysosome, Secreted |
| Calculated MW: | 27kDa |
| Observed MW: | 28kDa |
 | Western blot - IFI30 Polyclonal Antibody (CAB12995) |
| Synonyms: | IFI30, GILT, IFI-30, IP-30, IP30 |
| Background: | The protein encoded by this gene is a lysosomal thiol reductase that at low pH can reduce protein disulfide bonds. The enzyme is expressed constitutively in antigen-presenting cells and induced by gamma-interferon in other cell types. This enzyme has an important role in MHC class II-restricted antigen processing. |
| UniProt Protein Function: | IFI30: Lysosomal thiol reductase that can reduce protein disulfide bonds. May facilitate the complete unfolding of proteins destined for lysosomal degradation. Plays an important role in antigen processing. Facilitates the generation of MHC class II- restricted epitodes from disulfide bond-containing antigen by the endocytic reduction of disulfide bonds. Facilitates also MHC class I-restricted recognition of exogenous antigens containing disulfide bonds by CD8+ T-cells or crosspresentation. Belongs to the GILT family. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; EC 1.8.-.-; Secreted Chromosomal Location of Human Ortholog: 19p13.1 Cellular Component: lysosomal lumen; intracellular membrane-bound organelle; lysosome; cytoplasm; extracellular region; plasma membrane; cell junction Molecular Function:oxidoreductase activity, acting on sulfur group of donors Biological Process: protein stabilization; negative regulation of fibroblast proliferation; cytokine and chemokine mediated signaling pathway; antigen processing and presentation of exogenous peptide antigen via MHC class I; antigen processing and presentation of exogenous peptide antigen via MHC class II |
| NCBI Summary: | The protein encoded by this gene is a lysosomal thiol reductase that at low pH can reduce protein disulfide bonds. The enzyme is expressed constitutively in antigen-presenting cells and induced by gamma-interferon in other cell types. This enzyme has an important role in MHC class II-restricted antigen processing. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P13284 |
| NCBI GenInfo Identifier: | 29150261 |
| NCBI Gene ID: | 10437 |
| NCBI Accession: | NP_006323.2 |
| UniProt Secondary Accession: | P13284,Q76MF9, Q8NEI4, Q8WU77, Q9UL08, |
| UniProt Related Accession: | P13284 |
| Molecular Weight: | 27,964 Da |
| NCBI Full Name: | gamma-interferon-inducible lysosomal thiol reductase preproprotein |
| NCBI Synonym Full Names: | interferon, gamma-inducible protein 30 |
| NCBI Official Symbol: | IFI30 |
| NCBI Official Synonym Symbols: | GILT; IP30; IP-30; IFI-30 |
| NCBI Protein Information: | gamma-interferon-inducible lysosomal thiol reductase; gamma-interferon-inducible protein IP-30; interferon gamma-inducible protein 30 preproprotein; legumaturain |
| UniProt Protein Name: | Gamma-interferon-inducible lysosomal thiol reductase |
| UniProt Synonym Protein Names: | Gamma-interferon-inducible protein IP-30; Legumaturain |
| Protein Family: | GILT-like protein |
| UniProt Gene Name: | IFI30 |
| UniProt Entry Name: | GILT_HUMAN |
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