Cell Biology Antibodies 12
Anti-IER3 Antibody (CAB8566)
(No reviews yet)
Write a Review
- SKU:
- CAB8566
- Product Type:
- Antibody
- Applications:
- WB
- Applications:
- IHC
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-IER3 Antibody |
| Antibody SKU: | CAB8566 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 50 to the C-terminus of human IER3 (NP_003888.2). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 |
| Reactivity: | Human, Mouse |
| Positive Samples: | HT-1080, MCF7, SW480, HeLa, A-431 |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 50 to the C-terminus of human IER3 (NP_003888.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | GRPS ASRG HRKR SRRV LYPR VVRR QLPV EEPN PAKR LLFL LLTI VFCQ ILMA EEGV PAPL PPED APNA ASLA PTPV SAVL EPFN LTSE PSDY ALDL STFL QQHP AAF |
| Gene ID: | 8870 |
| Uniprot: | P46695 |
| Cellular Location: | Membrane, Single-pass type II membrane protein |
| Calculated MW: | 16kDa |
| Observed MW: | 17kDa |
| Synonyms: | IER3, DIF-2, DIF2, GLY96, IEX-1, IEX-1L, IEX1, PRG1 |
| Background: | This gene functions in the protection of cells from Fas- or tumor necrosis factor type alpha-induced apoptosis. Partially degraded and unspliced transcripts are found after virus infection in vitro, but these transcripts are not found in vivo and do not generate a valid protein. |
| UniProt Protein Function: | IEX-1: May play a role in the ERK signaling pathway by inhibiting the dephosphorylation of ERK by phosphatase PP2A- PPP2R5C holoenzyme. Acts also as an ERK downstream effector mediating survival. Belongs to the IER3 family. |
| UniProt Protein Details: | Protein type:Apoptosis; Membrane protein, integral Chromosomal Location of Human Ortholog: 6p21.3 Cellular Component: cytosol; nucleus Molecular Function:protein binding Biological Process: anatomical structure morphogenesis; apoptosis; regulation of phosphoinositide 3-kinase cascade |
| NCBI Summary: | This gene functions in the protection of cells from Fas- or tumor necrosis factor type alpha-induced apoptosis. Partially degraded and unspliced transcripts are found after virus infection in vitro, but these transcripts are not found in vivo and do not generate a valid protein. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P46695 |
| NCBI GenInfo Identifier: | 317373569 |
| NCBI Gene ID: | 8870 |
| NCBI Accession: | P46695.4 |
| UniProt Secondary Accession: | P46695,Q5SU30, Q92691, Q93044, |
| UniProt Related Accession: | P46695 |
| Molecular Weight: | 16,903 Da |
| NCBI Full Name: | Radiation-inducible immediate-early gene IEX-1 |
| NCBI Synonym Full Names: | immediate early response 3 |
| NCBI Official Symbol: | IER3 |
| NCBI Official Synonym Symbols: | DIF2; IEX1; PRG1; DIF-2; GLY96; IEX-1; IEX-1L |
| NCBI Protein Information: | radiation-inducible immediate-early gene IEX-1 |
| UniProt Protein Name: | Radiation-inducible immediate-early gene IEX-1 |
| UniProt Synonym Protein Names: | Differentiation-dependent gene 2 protein; Protein DIF-2; Immediate early protein GLY96; Immediate early response 3 protein; PACAP-responsive gene 1 protein; Protein PRG1 |
| Protein Family: | Radiation-inducible immediate-early gene |
| UniProt Gene Name: | IER3 |
| UniProt Entry Name: | IEX1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using IER3 Antibody (CAB8566) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded mouse stomach using IER3 antibody (CAB8566) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human gastric cancer using IER3 antibody (CAB8566) at dilution of 1:100 (40x lens). |
View AllClose
Related Products
Human anti-EPO antibody(anti-Erythropoietin antibody) ELISA Kit
system_update_altDatasheet - तकनीकी मैनुअलsystem_update_altMSDS - तकनीक