Immunology Antibodies 2
Anti-IDO1 Antibody (CAB1614)
- SKU:
- CAB1614
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
| Antibody Name: | Anti-IDO1 Antibody |
| Antibody SKU: | CAB1614 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 204-403 of human IDO1 (NP_002155.1). |
| Application: | IF |
| Recommended Dilution: | IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 204-403 of human IDO1 (NP_002155.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | ASCL EKAL QVFH QIHD HVNP KAFF SVLR IYLS GWKG NPQL SDGL VYEG FWED PKEF AGGS AGQS SVFQ CFDV LLGI QQTA GGGH AAQF LQDM RRYM PPAH RNFL CSLE SNPS VREF VLSK GDAG LREA YDAC VKAL VSLR SYHL QIVT KYIL IPAS QQPK ENKT SEDP SKLE AKGT GGTD LMNF LKTV RSTT EKSL LKEG |
| Gene ID: | 3620 |
| Uniprot: | P14902 |
| Cellular Location: | Cytoplasm, cytosol |
| Calculated MW: | 45kDa |
| Observed MW: | 50kDa |
| Synonyms: | IDO1, IDO, IDO-1, INDO, indoleamine 2 |
| Background: | This gene encodes indoleamine 2, 3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan. |
| UniProt Protein Function: | INDO: Catalyzes the cleavage of the pyrrol ring of tryptophan and incorporates both atoms of a molecule of oxygen. Belongs to the indoleamine 2,3-dioxygenase family. |
| UniProt Protein Details: | Protein type:Amino Acid Metabolism - tryptophan; Cell cycle regulation; EC 1.13.11.52; Oxidoreductase Chromosomal Location of Human Ortholog: 8p12-p11 Cellular Component: stereocilium bundle; smooth muscle contractile fiber; cytosol Molecular Function:electron carrier activity; metal ion binding; heme binding; indoleamine 2,3-dioxygenase activity; tryptophan 2,3-dioxygenase activity Biological Process: regulation of activated T cell proliferation; positive regulation of T-helper 2 type immune response; negative regulation of interleukin-10 production; positive regulation of chronic inflammatory response; tryptophan catabolic process to kynurenine; positive regulation of interleukin-12 production; response to lipopolysaccharide; female pregnancy; negative regulation of T cell proliferation; cytokine production during acute inflammatory response; multicellular organismal response to stress; tryptophan catabolic process; positive regulation of T cell tolerance induction |
| NCBI Summary: | This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.[provided by RefSeq, Feb 2011] |
| UniProt Code: | P14902 |
| NCBI GenInfo Identifier: | 123948 |
| NCBI Gene ID: | 3620 |
| NCBI Accession: | P14902.1 |
| UniProt Related Accession: | P14902 |
| Molecular Weight: | 45kDa |
| NCBI Full Name: | Indoleamine 2,3-dioxygenase 1 |
| NCBI Synonym Full Names: | indoleamine 2,3-dioxygenase 1 |
| NCBI Official Symbol: | IDO1 |
| NCBI Official Synonym Symbols: | IDO; INDO; IDO-1 |
| NCBI Protein Information: | indoleamine 2,3-dioxygenase 1 |
| UniProt Protein Name: | Indoleamine 2,3-dioxygenase 1 |
| UniProt Synonym Protein Names: | Indoleamine-pyrrole 2,3-dioxygenase |
| Protein Family: | L-isoleucine-4-hydroxylase |
| UniProt Gene Name: | IDO1 |
| UniProt Entry Name: | I23O1_HUMAN |
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