Metabolism Antibodies 1

Anti-IDI2 Antibody (CAB14434)

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SKU:
CAB14434
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Metabolism

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-IDI2 Antibody
Antibody SKU:CAB14434
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 60-180 of human IDI2 (NP_150286.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:293T
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 60-180 of human IDI2 (NP_150286.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:NTKN RILI QQRS DTKV TFPG YFTD SCSS HPLY NPAE LEEK DAIG VRRA AQRR LQAE LGIP GEQI SPED IVFM TIYH HKAK SDRI WGEH EICY LLLV RKNV TLNP DPSE TKSI LYLS QEEL W
Gene ID:91734
Uniprot:Q9BXS1
Cellular Location:Peroxisome
Calculated MW:26kDa
Observed MW:27kDa
Synonyms:IDI2, IPPI2
Background:The protein encoded by this gene catalyzes the conversion of isopentenyl diphosphate to dimethylallyl diphosphate, which is a precursor for the synthesis of cholesterol and other isoprenoids. This gene, which is a product of an ancestral gene duplication event, encodes a protein that may be involved in the aggregation of alpha-synuclein in the cerebral cortex of patients with Lewy body disease. In addition, segmental copy number gains in this locus have been associated with sporadic amyotrophic lateral sclerosis.
UniProt Protein Function:IDI2: Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). Belongs to the IPP isomerase type 1 family.
UniProt Protein Details:

Protein type:Secondary Metabolites Metabolism - terpenoid backbone biosynthesis; EC 5.3.3.2; Isomerase

Chromosomal Location of Human Ortholog: 10p15.3

Cellular Component: peroxisome; cytosol

Molecular Function:hydrolase activity; metal ion binding; isopentenyl-diphosphate delta-isomerase activity

Biological Process: isoprenoid biosynthetic process; isopentenyl diphosphate metabolic process; dimethylallyl diphosphate biosynthetic process; cholesterol biosynthetic process

UniProt Code:Q9BXS1
NCBI GenInfo Identifier:15147242
NCBI Gene ID:91734
NCBI Accession:NP_150286.1
UniProt Related Accession:Q9BXS1
Molecular Weight:26,753 Da
NCBI Full Name:isopentenyl-diphosphate delta-isomerase 2
NCBI Synonym Full Names:isopentenyl-diphosphate delta isomerase 2
NCBI Official Symbol:IDI2  
NCBI Official Synonym Symbols:IPPI2  
NCBI Protein Information:isopentenyl-diphosphate delta-isomerase 2; IPP isomerase 2; diphosphate dimethylallyl diphosphate isomerase 2; isopentenyl pyrophosphate isomerase 2; isopentenyl-diphosphate Delta-isomerase 2
UniProt Protein Name:Isopentenyl-diphosphate delta-isomerase 2
UniProt Synonym Protein Names:Isopentenyl pyrophosphate isomerase 2; IPP isomerase 2; IPPI2
Protein Family:Isopentenyl-diphosphate Delta-isomerase
UniProt Gene Name:IDI2  
UniProt Entry Name:IDI2_HUMAN
Anti-IDI2 Antibody (CAB14434)Western blot analysis of extracts of 293T cells, using IDI2 antibody (CAB14434) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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system_update_altDatasheetHuman IPPI2/IDI2 Recombinant Protein Isopentenyl Pyrophosphate Isomerase 2 (IDI2) belongs to the IPP isomerase type 1 family. Both isozymes, IDI1 and IDI2 are localized