| UniProt Protein Function: | ID4: ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding. |
| UniProt Protein Details: | Protein type:Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 6p22.3 Cellular Component: cytoplasm; nucleus Molecular Function:protein binding; protein dimerization activity; transcription corepressor activity Biological Process: cerebral cortex neuron differentiation; circadian rhythm; fat cell differentiation; G1/S transition of mitotic cell cycle; hippocampus development; myelination in the central nervous system; negative regulation of astrocyte differentiation; negative regulation of fat cell differentiation; negative regulation of neuron differentiation; negative regulation of oligodendrocyte differentiation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; neuroblast proliferation; positive regulation of cell proliferation; positive regulation of osteoblast differentiation; positive regulation of transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent |
| NCBI Summary: | This gene encodes a member of the inhibitor of DNA binding (ID) protein family. These proteins are basic helix-loop-helix transcription factors which can act as tumor suppressors but lack DNA binding activity. Consequently, the activity of the encoded protein depends on the protein binding partner. [provided by RefSeq, Dec 2011] |
| UniProt Code: | P47928 |
| NCBI GenInfo Identifier: | 1352422 |
| NCBI Gene ID: | 3400 |
| NCBI Accession: | P47928.1 |
| UniProt Secondary Accession: | P47928,Q13005, |
| UniProt Related Accession: | P47928 |
| Molecular Weight: | 16,622 Da |
| NCBI Full Name: | DNA-binding protein inhibitor ID-4 |
| NCBI Synonym Full Names: | inhibitor of DNA binding 4, HLH protein |
| NCBI Official Symbol: | ID4 |
| NCBI Official Synonym Symbols: | IDB4; bHLHb27 |
| NCBI Protein Information: | DNA-binding protein inhibitor ID-4 |
| UniProt Protein Name: | DNA-binding protein inhibitor ID-4 |
| UniProt Synonym Protein Names: | Class B basic helix-loop-helix protein 27; bHLHb27; Inhibitor of DNA binding 4; Inhibitor of differentiation 4 |
| Protein Family: | DNA-binding protein inhibitor |
| UniProt Gene Name: | ID4 |
| UniProt Entry Name: | ID4_HUMAN |
