Cell Biology Antibodies 9
Anti-ID3 Antibody (CAB5375)
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- SKU:
- CAB5375
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-ID3 Antibody |
| Antibody SKU: | CAB5375 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-119 of human ID3 (NP_002158.3). |
| Application: | IHC IF |
| Recommended Dilution: | IHC 1:50 - 1:200 IF 1:50 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-119 of human ID3 (NP_002158.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MKAL SPVR GCYE AVCC LSER SLAI ARGR GKGP AAEE PLSL LDDM NHCY SRLR ELVP GVPR GTQL SQVE ILQR VIDY ILDL QVVL AEPA PGPP DGPH LPIQ TAEL TPEL VISN DKRS FCH |
| Gene ID: | 3399 |
| Uniprot: | Q02535 |
| Cellular Location: | Nucleus |
| Calculated MW: | 12kDa |
| Observed MW: | Refer to figures |
| Synonyms: | ID3, HEIR-1, bHLHb25 |
| Background: | The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with other HLH proteins. However, the encoded protein lacks a basic DNA-binding domain and therefore inhibits the DNA binding of any HLH protein with which it interacts. |
| UniProt Protein Function: | ID3: ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding. ID-3 inhibits the binding of E2A-containing protein complexes to muscle creatine kinase E-box enhancer. May inhibit other transcription factors. Induced by phorbol 12-myristate 13-acetate (PMA). Interacts with COPS5 and COPS7A. Homodimer, and heterodimer with other HLH proteins. |
| UniProt Protein Details: | Protein type:Transcription, coactivator/corepressor; DNA-binding Chromosomal Location of Human Ortholog: 1p36.13-p36.12 Cellular Component: microtubule cytoskeleton; nucleoplasm; nucleus Molecular Function:protein binding; transcription corepressor activity Biological Process: multicellular organismal development; negative regulation of transcription factor activity; negative regulation of transcription, DNA-dependent |
| NCBI Summary: | The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with other HLH proteins. However, the encoded protein lacks a basic DNA-binding domain and therefore inhibits the DNA binding of any HLH protein with which it interacts. [provided by RefSeq, Aug 2011] |
| UniProt Code: | Q02535 |
| NCBI GenInfo Identifier: | 322510035 |
| NCBI Gene ID: | 3399 |
| NCBI Accession: | Q02535.2 |
| UniProt Secondary Accession: | Q02535,O75641, A8K1T8, |
| UniProt Related Accession: | Q02535 |
| Molecular Weight: | 12,999 Da |
| NCBI Full Name: | DNA-binding protein inhibitor ID-3 |
| NCBI Synonym Full Names: | inhibitor of DNA binding 3, HLH protein |
| NCBI Official Symbol: | ID3 |
| NCBI Official Synonym Symbols: | HEIR-1; bHLHb25 |
| NCBI Protein Information: | DNA-binding protein inhibitor ID-3 |
| UniProt Protein Name: | DNA-binding protein inhibitor ID-3 |
| UniProt Synonym Protein Names: | Class B basic helix-loop-helix protein 25; bHLHb25; Helix-loop-helix protein HEIR-1; ID-like protein inhibitor HLH 1R21; Inhibitor of DNA binding 3; Inhibitor of differentiation 3 |
| Protein Family: | DNA-binding protein inhibitor |
| UniProt Gene Name: | ID3 |
| UniProt Entry Name: | ID3_HUMAN |
 | Immunohistochemistry of paraffin-embedded rat brain using ID3 antibody (CAB5375) at dilution of 1:200 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse pancreas using ID3 antibody (CAB5375) at dilution of 1:200 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human lung cancer using ID3 antibody (CAB5375) at dilution of 1:200 (40x lens). |
 | Immunofluorescence analysis of HeLa cells using ID3 antibody (CAB5375). |
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