Immunology Antibodies 2
Anti-ICOSL Antibody (CAB7080)
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- SKU:
- CAB7080
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
| Antibody Name: | Anti-ICOSL Antibody |
| Antibody SKU: | CAB7080 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 19-256 of human ICOSL (NP_056074.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HL-60, BT-474, Mouse heart, Mouse brain, Rat spleen |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 19-256 of human ICOSL (NP_056074.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | DTQE KEVR AMVG SDVE LSCA CPEG SRFD LNDV YVYW QTSE SKTV VTYH IPQN SSLE NVDS RYRN RALM SPAG MLRG DFSL RLFN VTPQ DEQK FHCL VLSQ SLGF QEVL SVEV TLHV AANF SVPV VSAP HSPS QDEL TFTC TSIN GYPR PNVY WINK TDNS LLDQ ALQN DTVF LNMR GLYD VVSV LRIA RTPS VNIG CCIE NVLL QQNL TVGS QTGN DIGE RDKI TENP VSTG EKNA AT |
| Gene ID: | 23308 |
| Uniprot: | O75144 |
| Cellular Location: | Membrane, Single-pass type I membrane protein |
| Calculated MW: | 20kDa/33kDa/34kDa |
| Observed MW: | 50-70kDa |
| Synonyms: | ICOSLG, B7-H2, B7H2, B7RP-1, B7RP1, CD275, GL50, ICOS-L, ICOSL, LICOS |
| Background: |
| UniProt Protein Function: | ICOSLG: Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co- stimulating memory T-cell function. Belongs to the immunoglobulin superfamily. BTN/MOG family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 21q22.3 Cellular Component: plasma membrane Molecular Function:receptor binding Biological Process: positive regulation of activated T cell proliferation; T cell costimulation |
| UniProt Code: | O75144 |
| NCBI GenInfo Identifier: | 19855066 |
| NCBI Gene ID: | 102723996 |
| NCBI Accession: | O75144.2 |
| UniProt Secondary Accession: | O75144,Q9HD18, Q9NRQ1, A8MUZ1, |
| Molecular Weight: | 20,120 Da |
| NCBI Full Name: | ICOS ligand |
| NCBI Official Symbol: | LOC102723996 |
| NCBI Protein Information: | ICOS ligand |
| UniProt Protein Name: | ICOS ligand |
| UniProt Synonym Protein Names: | B7 homolog 2; B7-H2; B7-like protein Gl50; B7-related protein 1; B7RP-1; CD_antigen: CD275 |
| UniProt Gene Name: | ICOSLG |
 | Western blot analysis of extracts of various cell lines, using ICOSL antibody (CAB7080) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded human skin carcinoma using ICOSL Antibody (CAB7080) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human kidney using ICOSL Antibody (CAB7080) at dilution of 1:100 (40x lens). |
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