Cell Biology Antibodies 17
Anti-ICOS Antibody (CAB5130)
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- SKU:
- CAB5130
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-ICOS Antibody |
| Antibody SKU: | CAB5130 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human ICOS |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HL-60, Mouse thymus, Mouse spleen, Rat thymus, Rat spleen |
| Immunogen: | A synthesized peptide derived from human ICOS |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 29851 |
| Uniprot: | Q9Y6W8 |
| Cellular Location: | |
| Calculated MW: | 22kDa |
| Observed MW: | 22KDa |
| Synonyms: | AILIM, CD278, CVID1 |
| Background: | The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation. [provided by RefSeq, Jul 2008] |
| UniProt Protein Function: | ICOS: Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up- regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up- regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre- activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes. Defects in ICOS are the cause of immunodeficiency common variable type 1 (CVID1). CVID1 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be lo. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 2q33 Cellular Component: integral to plasma membrane; extracellular region; plasma membrane; external side of plasma membrane Biological Process: cell-cell adhesion; T cell tolerance induction; T cell costimulation; immune response Disease: Immunodeficiency, Common Variable, 2; Immunodeficiency, Common Variable, 1 |
| NCBI Summary: | The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9Y6W8 |
| NCBI GenInfo Identifier: | 50400701 |
| NCBI Gene ID: | 29851 |
| NCBI Accession: | Q9Y6W8.1 |
| UniProt Secondary Accession: | Q9Y6W8,Q8N6W8, |
| UniProt Related Accession: | Q9Y6W8 |
| Molecular Weight: | 199 |
| NCBI Full Name: | Inducible T-cell costimulator |
| NCBI Synonym Full Names: | inducible T-cell co-stimulator |
| NCBI Official Symbol: | ICOS |
| NCBI Official Synonym Symbols: | AILIM; CD278; CVID1 |
| NCBI Protein Information: | inducible T-cell costimulator; inducible costimulator; activation-inducible lymphocyte immunomediatory molecule |
| UniProt Protein Name: | Inducible T-cell costimulator |
| UniProt Synonym Protein Names: | Activation-inducible lymphocyte immunomediatory molecule; CD_antigen: CD278 |
| Protein Family: | ICOS ligand |
| UniProt Gene Name: | ICOS |
| UniProt Entry Name: | ICOS_HUMAN |
 | Western blot - ICOS Rabbit mAb (CAB5130) |
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