Epigenetics & Nuclear Signaling Antibodies 1

Anti-ICE2 Antibody (CAB12871)

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SKU:
CAB12871
Product Type:
Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling

Description

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Antibody Name:Anti-ICE2 Antibody
Antibody SKU:CAB12871
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 660-800 of human ICE2 (NP_078887.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:1000
Reactivity:Mouse
Positive Samples:Mouse brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 660-800 of human ICE2 (NP_078887.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:SRKV PELP LMNL ENSK QPSV SEQL SGPS DSSS WPKS GWPS AFQK PKGR LPYE LQDY VEDT SEYL APQE GNFV YKLF SLQD LLLL VRCS VQRI ETRP RSKK RKKI RRQF PVYV LPKV EYQA CYGV EALT ESEL CRLW TESL L
Gene ID:79664
Uniprot:Q659A1
Cellular Location:Nucleus
Calculated MW:8kDa/110kDa
Observed MW:110kDa
Synonyms:ICE2, BRCC1, NARG2
Background:This gene encodes a protein component of the little elongation complex (LEC), which plays a role in small nuclear RNA (snRNA) transcription. The LEC regulates snRNA transcription by enhancing both RNA Polymerase II occupancy and transcriptional elongation. The encoded protein and other LEC components have been shown to localize to Cajal bodies, which are sites of ribonucleoprotein (RNP) complex assembly. Pseudogenes of this gene have been identified on chromosomes 3 and 4.
UniProt Protein Function:NARG2: 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Unknown function

Chromosomal Location of Human Ortholog: 15q22.2

Cellular Component: Cajal body; cytosol; nuclear body; nucleoplasm; transcription elongation factor complex

Molecular Function:protein binding

Biological Process: positive regulation of transcription from RNA polymerase III promoter; snRNA transcription from RNA polymerase II promoter; snRNA transcription from RNA polymerase III promoter

NCBI Summary:This gene encodes a protein component of the little elongation complex (LEC), which plays a role in small nuclear RNA (snRNA) transcription. The LEC regulates snRNA transcription by enhancing both RNA Polymerase II occupancy and transcriptional elongation. The encoded protein and other LEC components have been shown to localize to Cajal bodies, which are sites of ribonucleoprotein (RNP) complex assembly. Pseudogenes of this gene have been identified on chromosomes 3 and 4. [provided by RefSeq, May 2017]
UniProt Code:Q659A1
NCBI GenInfo Identifier:156632596
NCBI Gene ID:79664
NCBI Accession:Q659A1.2
UniProt Secondary Accession:Q659A1,Q05CT1, Q3B7W6, Q63HP4, Q658Q0, Q68CN8, Q6IPW7 Q6UX23, Q71H65, Q96CY5, Q9HAA2, B2RU08,
UniProt Related Accession:Q659A1
Molecular Weight:110kDa
NCBI Full Name:Little elongation complex subunit 2
NCBI Synonym Full Names:interactor of little elongation complex ELL subunit 2
NCBI Official Symbol:ICE2  
NCBI Official Synonym Symbols:BRCC1; NARG2  
NCBI Protein Information:little elongation complex subunit 2
UniProt Protein Name:Little elongation complex subunit 2
UniProt Synonym Protein Names:Interactor of little elongator complex ELL subunit 2; NMDA receptor-regulated protein 2
Protein Family:Protein
UniProt Gene Name:ICE2  
Anti-ICE2 Antibody (CAB12871)Western blot analysis of extracts of mouse brain, using ICE2 antibody (CAB12871) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s.
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