Cell Biology Antibodies 11

Anti-ICAM4 Antibody (CAB7438)

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SKU:
CAB7438
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-ICAM4 Antibody
Antibody SKU:CAB7438
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 20-140 of human ICAM4 (NP_001034221.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:HepG2, Jurkat, SW480, Mouse brain, Mouse spleen, Mouse heart, Mouse pancreas, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 20-140 of human ICAM4 (NP_001034221.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:VGSA LGRR TKRA QSPK GSPL APSG TSVP FWVR MSPE FVAV QPGK SVQL NCSN SCPQ PQNS SLRT PLRQ GKTL RGPG WVSY QLLD VRAW SSLA HCLV TCAG KTRW ATSR ITAY SVPG GLLG G
Gene ID:3386
Uniprot:Q14773
Cellular Location:Cell membrane, Secreted, Single-pass type I membrane protein
Calculated MW:25kDa/29kDa
Observed MW:29kDa
Synonyms:ICAM4, CD242, LW
Background:This gene encodes the Landsteiner-Wiener (LW) blood group antigen(s) that belongs to the immunoglobulin (Ig) superfamily, and that shares similarity with the intercellular adhesion molecule (ICAM) protein family. This ICAM protein contains 2 Ig-like C2-type domains and binds to the leukocyte adhesion LFA-1 protein. The molecular basis of the LW(A)/LW(B) blood group antigens is a single aa variation at position 100; Gln-100=LW(A) and Arg-100=LW(B). Alternative splicing results in multiple transcript variants encoding distinct isoforms.
UniProt Protein Function:ICAM4: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM4 is also a ligand for alpha-4/beta-1 and alpha-V integrins. Belongs to the immunoglobulin superfamily. ICAM family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral

Chromosomal Location of Human Ortholog: 19p13.2-cen

Disease: Blood Group System, Landsteiner-wiener

NCBI Summary:This gene encodes the Landsteiner-Wiener (LW) blood group antigen(s) that belongs to the immunoglobulin (Ig) superfamily, and that shares similarity with the intercellular adhesion molecule (ICAM) protein family. This ICAM protein contains 2 Ig-like C2-type domains and binds to the leukocyte adhesion LFA-1 protein. The molecular basis of the LW(A)/LW(B) blood group antigens is a single aa variation at position 100; Gln-100=LW(A) and Arg-100=LW(B). Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
UniProt Code:Q14773
NCBI GenInfo Identifier:2497309
NCBI Gene ID:3386
NCBI Accession:Q14773.1
UniProt Secondary Accession:Q14773,Q14771, Q14772, Q16375, Q9BWR0, A0M8X2,
UniProt Related Accession:Q14773
Molecular Weight:271
NCBI Full Name:Intercellular adhesion molecule 4
NCBI Synonym Full Names:intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
NCBI Official Symbol:ICAM4  
NCBI Official Synonym Symbols:LW; CD242  
NCBI Protein Information:intercellular adhesion molecule 4; CD242 antigen; LW blood group protein; Landsteiner-Wiener blood group antigen a; Landsteiner-Wiener blood group glycoprotein; intercellular adhesion molecule 4 (LW blood group); intercellular adhesion molecule 4 isoform 3 anitgen LWa
UniProt Protein Name:Intercellular adhesion molecule 4
UniProt Synonym Protein Names:Landsteiner-Wiener blood group glycoprotein; LW blood group protein; CD_antigen: CD242
Protein Family:Intercellular adhesion molecule
UniProt Gene Name:ICAM4  
UniProt Entry Name:ICAM4_HUMAN
Anti-ICAM4 Antibody (CAB7438)Western blot analysis of extracts of various cell lines, using ICAM4 antibody (CAB7438) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s.
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