Cell Biology Antibodies 8

Anti-ICAM2 Antibody (CAB2038)

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SKU:
CAB2038
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-ICAM2 Antibody
Antibody SKU:CAB2038
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 25-223 of human ICAM2 (NP_000864.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:Jurkat, Mouse heart
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 25-223 of human ICAM2 (NP_000864.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:KVFE VHVR PKKL AVEP KGSL EVNC STTC NQPE VGGL ETSL DKIL LDEQ AQWK HYLV SNIS HDTV LQCH FTCS GKQE SMNS NVSV YQPP RQVI LTLQ PTLV AVGK SFTI ECRV PTVE PLDS LTLF LFRG NETL HYET FGKA APAP QEAT ATFN STAD REDG HRNF SCLA VLDL MSRG GNIF HKHS APKM LEIY EPVS DSQ
Gene ID:3384
Uniprot:P13598
Cellular Location:Membrane, Single-pass type I membrane protein
Calculated MW:30kDa
Observed MW:55kDa
Synonyms:ICAM2, CD102
Background:The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance. Several transcript variants encoding the same protein have been found for this gene.
UniProt Protein Function:ICAM2: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen- specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance. Belongs to the immunoglobulin superfamily. ICAM family.
UniProt Protein Details:

Protein type:Cell adhesion; Membrane protein, integral

Chromosomal Location of Human Ortholog: 17q23.3

Cellular Component: membrane; integral to plasma membrane; plasma membrane; uropod

Molecular Function:integrin binding

Biological Process: extracellular matrix organization and biogenesis; cell-cell adhesion; regulation of immune response; cell adhesion

NCBI Summary:The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:P13598
NCBI GenInfo Identifier:115502404
NCBI Gene ID:3384
NCBI Accession:P13598.2
UniProt Secondary Accession:P13598,Q14600,
UniProt Related Accession:P13598
Molecular Weight:30,654 Da
NCBI Full Name:Intercellular adhesion molecule 2
NCBI Synonym Full Names:intercellular adhesion molecule 2
NCBI Official Symbol:ICAM2  
NCBI Official Synonym Symbols:CD102  
NCBI Protein Information:intercellular adhesion molecule 2; ICAM-2
UniProt Protein Name:Intercellular adhesion molecule 2
UniProt Synonym Protein Names:CD_antigen: CD102
Protein Family:Intercellular adhesion molecule
UniProt Gene Name:ICAM2  
UniProt Entry Name:ICAM2_HUMAN
Anti-ICAM2 Antibody (CAB2038)Western blot analysis of extracts of various cell lines, using ICAM2 antibody (CAB2038) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020).
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