Anti-ICAM-1/CD54 Antibody (CAB20216)
- SKU:
- CAB20216
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- BB2
- Synonyms:
- CD54
- Synonyms:
- P3.58
- Synonyms:
- ICAM1
- Research Area:
- Cell Biology
Description
| Product Name: | ICAM-1/CD54 Rabbit mAb |
| Product Code: | CAB20216 |
| Size: | 50uL, 100uL |
| Synonyms: | BB2, CD54, P3.58, ICAM1 |
| Applications: | IF, FC, ELISA |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human ICAM-1/CD54 |
| Applications: | IF, FC, ELISA |
| Recommended Dilutions: | Elisa 1:500 - 1:2000 FC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human |
| Immunogen: | A synthesized peptide derived from human ICAM-1/CD54 |
| Purification Method: | Affinity purification |
| Storage: | Store at 4°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% thimerosal, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 3383 |
| Uniprot: | P05362 |
| Cellular Location: | Membrane, Single-pass type I membrane protein |
| Calculated MW: | 89kDa |
| Observed MW: | Refer to figures |
| UniProt Protein Function: | ICAM1: a type I membrane protein of the immunoglobulin superfamily. Is a ligand for the leukocyte adhesion LFA-1 protein (Integrin alpha-L/beta-2) and a Rhinovirus receptor. Typically expressed on endothelial cells and cells of the immune system. ICAM1 binds to integrins of type CD11a / CD18, or CD11b / CD18. Its expression is activated by p53 in an NF-kappaB-independent manner. Induced by TNFalpha in a process that involves IKKbeta. |
| UniProt Protein Details: | Protein type:Immunoglobulin superfamily; Membrane protein, integral; Cell adhesion Chromosomal Location of Human Ortholog: 19p13.3-p13.2 Cellular Component: extracellular space; focal adhesion; cell surface; membrane; integral to plasma membrane; plasma membrane; immunological synapse; external side of plasma membrane Molecular Function:viral receptor activity; integrin binding; protein binding; transmembrane receptor activity; receptor activity Biological Process: entry of virus into host cell; extracellular matrix organization and biogenesis; positive regulation of nitric oxide biosynthetic process; T cell antigen processing and presentation; response to organic cyclic substance; activation of NF-kappaB transcription factor; positive regulation of cellular extravasation; regulation of cell shape; leukocyte adhesion; cellular response to nutrient levels; sensory perception of sound; ovarian follicle development; T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell; membrane to membrane docking; response to sulfur dioxide; cell adhesion; regulation of leukocyte mediated cytotoxicity; acute inflammatory response to antigenic stimulus; response to drug; regulation of cell adhesion; virion attachment, binding of host cell surface receptor; negative regulation of calcium ion transport; regulation of immune response; cytokine and chemokine mediated signaling pathway; response to amphetamine; cell aging; response to amino acid stimulus; heterophilic cell adhesion; positive regulation of peptidyl-tyrosine phosphorylation; response to ethanol; response to copper ion; positive regulation of actin filament polymerization; positive regulation of vasoconstriction; adhesion to host; cell adhesion mediated by integrin; response to ionizing radiation; leukocyte migration Disease: Malaria, Susceptibility To |
| NCBI Summary: | This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P05362 |
| NCBI GenInfo Identifier: | 68067956 |
| NCBI Gene ID: | 3383 |
| NCBI Accession: | P05362.2 |
| UniProt Secondary Accession: | P05362,Q5NKV7, Q96B50, B2R6M3, |
| UniProt Related Accession: | P05362 |
| Molecular Weight: | |
| NCBI Full Name: | Intercellular adhesion molecule 1 |
| NCBI Synonym Full Names: | intercellular adhesion molecule 1 |
| NCBI Official Symbol: | ICAM1 |
| NCBI Official Synonym Symbols: | BB2; CD54; P3.58 |
| NCBI Protein Information: | intercellular adhesion molecule 1; ICAM-1; cell surface glycoprotein P3.58; major group rhinovirus receptor; intercellular adhesion molecule 1 (CD54), human rhinovirus receptor |
| UniProt Protein Name: | Intercellular adhesion molecule 1 |
| UniProt Synonym Protein Names: | Major group rhinovirus receptor; CD_antigen: CD54 |
| Protein Family: | Intercellular adhesion molecule |
| UniProt Gene Name: | ICAM1 |
| UniProt Entry Name: | ICAM1_HUMAN |
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