Metabolism Antibodies 3
Anti-IARS2 Antibody (CAB15861)
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- SKU:
- CAB15861
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
| Antibody Name: | Anti-IARS2 Antibody |
| Antibody SKU: | CAB15861 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 663-1012 of human IARS2 (NP_060530.3). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | LO2, A-431, NIH/3T3, Mouse liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 663-1012 of human IARS2 (NP_060530.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | EKMS KSLG NVIH PDVV VNGG QDQS KEPP YGAD VLRW WVAD SNVF TEVA IGPS VLNA ARDD ISKL RNTL RFLL GNVA DFNP ETDS IPVN DMYV IDQY MLHL LQDL ANKI TELY KQYD FGKV VRLL RTFY TREL SNFY FSII KDRL YCEK ENDP KRRS CQTA LVEI LDVI VRSF APIL PHLA EEVF QHIP YIKE PKSV FRTG WIST SSIW KKPG LEEA VESA CAMR DSFL GSIP GKNA AEYK VITV IEPG LLFE IIEM LQSE ETSS TSQL NELM MASE STLL AQEP REMT ADVI ELKG KFLI NLEG GDIR EESS YKVI VMPT TKEK CPRC WKYT AESS DTLC PRCA EVVS GK |
| Gene ID: | 55699 |
| Uniprot: | Q9NSE4 |
| Cellular Location: | Mitochondrion matrix |
| Calculated MW: | 113kDa |
| Observed MW: | 113kDa |
| Synonyms: | IARS2, CAGSSS, ILERS |
| Background: | Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAS, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of isoleucine-tRNA synthetase exist, a cytoplasmic form and a mitochondrial form. This gene encodes the mitochondrial isoleucine-tRNA synthetase which belongs to the class-I aminoacyl-tRNA synthetase family. |
| UniProt Protein Function: | IARS2: Belongs to the class-I aminoacyl-tRNA synthetase family. |
| UniProt Protein Details: | Protein type:EC 6.1.1.5; Ligase; Amino Acid Metabolism - valine, leucine and isoleucine biosynthesis; Mitochondrial; Translation Chromosomal Location of Human Ortholog: 1q41 Cellular Component: cytoplasm; cytosol; mitochondrial matrix; mitochondrion Molecular Function:isoleucine-tRNA ligase activity Biological Process: isoleucyl-tRNA aminoacylation; tRNA aminoacylation for protein translation Disease: Cataracts, Growth Hormone Deficiency, Sensory Neuropathy, Sensorineural Hearing Loss, And Skeletal Dysplasia |
| NCBI Summary: | Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAS, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of isoleucine-tRNA synthetase exist, a cytoplasmic form and a mitochondrial form. This gene encodes the mitochondrial isoleucine-tRNA synthetase which belongs to the class-I aminoacyl-tRNA synthetase family. [provided by RefSeq, Dec 2014] |
| UniProt Code: | Q9NSE4 |
| NCBI GenInfo Identifier: | 94730583 |
| NCBI Gene ID: | 55699 |
| NCBI Accession: | Q9NSE4.2 |
| UniProt Secondary Accession: | Q9NSE4,Q1M2P9, Q6PI85, Q7L439, Q86WU9, Q96D91, Q9H9Q8 Q9NW42, B2RPG8, |
| UniProt Related Accession: | Q9NSE4 |
| Molecular Weight: | 113,792 Da |
| NCBI Full Name: | Isoleucine--tRNA ligase, mitochondrial |
| NCBI Synonym Full Names: | isoleucyl-tRNA synthetase 2, mitochondrial |
| NCBI Official Symbol: | IARS2 |
| NCBI Official Synonym Symbols: | ILERS; CAGSSS |
| NCBI Protein Information: | isoleucine--tRNA ligase, mitochondrial |
| UniProt Protein Name: | Isoleucine--tRNA ligase, mitochondrial |
| UniProt Synonym Protein Names: | Isoleucyl-tRNA synthetase; IleRS |
| UniProt Gene Name: | IARS2 |
| UniProt Entry Name: | SYIM_HUMAN |
 | Western blot analysis of extracts of various cell lines, using IARS2 antibody (CAB15861) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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