Immunology Antibodies 2

Anti-HVEM/TNFRSF14 Antibody (CAB1969)

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SKU:
CAB1969
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Immunology

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-HVEM/TNFRSF14 Antibody
Antibody SKU:CAB1969
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 39-202 of human HVEM/TNFRSF14 (NP_003811.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:Raji
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 39-202 of human HVEM/TNFRSF14 (NP_003811.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:LPSC KEDE YPVG SECC PKCS PGYR VKEA CGEL TGTV CEPC PPGT YIAH LNGL SKCL QCQM CDPA MGLR ASRN CSRT ENAV CGCS PGHF CIVQ DGDH CAAC RAYA TSSP GQRV QKGG TESQ DTLC QNCP PGTF SPNG TLEE CQHQ TKCS WLVT KAGA GTSS SHWV
Gene ID:8764
Uniprot:Q92956
Cellular Location:Membrane, Single-pass type I membrane protein
Calculated MW:21kDa/30kDa
Observed MW:30kDa
Synonyms:TNFRSF14, ATAR, CD270, HVEA, HVEM, LIGHTR, TR2
Background:This gene encodes a member of the TNF (tumor necrosis factor) receptor superfamily. The encoded protein functions in signal transduction pathways that activate inflammatory and inhibitory T-cell immune response. It binds herpes simplex virus (HSV) viral envelope glycoprotein D (gD), mediating its entry into cells. Alternative splicing results in multiple transcript variants.
UniProt Protein Function:TNFRSF14: Receptor for BTLA. Receptor for TNFSF14/LIGHT and homotrimeric TNFSF1/lymphotoxin-alpha. Involved in lymphocyte activation. Plays an important role in HSV pathogenesis because it enhanced the entry of several wild-type HSV strains of both serotypes into CHO cells, and mediated HSV entry into activated human T-cells.
UniProt Protein Details:

Protein type:Receptor, misc.; Membrane protein, integral; Cell cycle regulation

Chromosomal Location of Human Ortholog: 1p36.32

Cellular Component: integral to plasma membrane; plasma membrane; external side of plasma membrane

Molecular Function:viral receptor activity; protein binding; tumor necrosis factor receptor activity; ubiquitin protein ligase binding

Biological Process: positive regulation of peptidyl-tyrosine phosphorylation; defense response to Gram-positive bacterium; entry of virus into host cell; cell surface receptor linked signal transduction; tumor necrosis factor-mediated signaling pathway; T cell costimulation; positive regulation of cytokine secretion during immune response; negative regulation of alpha-beta T cell proliferation; immune response; defense response to Gram-negative bacterium

NCBI Summary:This gene encodes a member of the TNF (tumor necrosis factor) receptor superfamily. The encoded protein functions in signal transduction pathways that activate inflammatory and inhibitory T-cell immune response. It binds herpes simplex virus (HSV) viral envelope glycoprotein D (gD), mediating its entry into cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
UniProt Code:Q92956
NCBI GenInfo Identifier:13878821
NCBI Gene ID:8764
NCBI Accession:Q92956.3
UniProt Secondary Accession:Q92956,Q6IB95, Q8N634, Q8WXR1, Q96J31, Q9UM65, B3KW30 B9DI89,
UniProt Related Accession:Q92956
Molecular Weight:283
NCBI Full Name:Tumor necrosis factor receptor superfamily member 14
NCBI Synonym Full Names:tumor necrosis factor receptor superfamily, member 14
NCBI Official Symbol:TNFRSF14  
NCBI Official Synonym Symbols:TR2; ATAR; HVEA; HVEM; CD270; LIGHTR  
NCBI Protein Information:tumor necrosis factor receptor superfamily member 14; CD40-like protein; herpes virus entry mediator A; tumor necrosis factor receptor-like gene2; tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)
UniProt Protein Name:Tumor necrosis factor receptor superfamily member 14
UniProt Synonym Protein Names:Herpes virus entry mediator A; Herpesvirus entry mediator A; HveA; Tumor necrosis factor receptor-like 2; TR2; CD_antigen: CD270
Protein Family:Tumor necrosis factor receptor superfamily
UniProt Gene Name:TNFRSF14  
UniProt Entry Name:TNR14_HUMAN
Anti-HVEM/TNFRSF14 Antibody (CAB1969)Western blot analysis of extracts of Raji cells, using HVEM/TNFRSF14 antibody (CAB1969) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST.
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