Signal Transduction Antibodies 3

Anti-HVCN1 Antibody (CAB8968)

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SKU:
CAB8968
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-HVCN1 Antibody
Antibody SKU:CAB8968
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human HVCN1 (NP_115745.2).
Application:WB
Recommended Dilution:WB 1:200 - 1:2000
Reactivity:Human
Positive Samples:Raji, B cells
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human HVCN1 (NP_115745.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MATW DEKA VTRR AKVA PAER MSKF LRHF TVVG DDYH AWNI NYKK WENE EEEE EEEQ PPPT PVSG EEGR AAAP DVAP APGP APRA PLDF RGML RKLF SSHR
Gene ID:84329
Uniprot:Q96D96
Cellular Location:Cell membrane, Membrane, Multi-pass membrane protein
Calculated MW:27kDa/29kDa/31kDa
Observed MW:25kDa
Synonyms:HVCN1, HV1, VSOP
Background:This gene encodes a voltage-gated protein channel protein expressed more highly in certain cells of the immune system. Phagocytic cells produce superoxide anions which require this channel protein, and in B cells this same process facilitates antibody production. This same channel protein, however, can also regulate functions in other cells including spermatozoa. Multiple transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:HVCN1: Mediates the voltage-dependent proton permeability of excitable membranes. Forms a proton-selective channel through which protons may pass in accordance with their electrochemical gradient. Proton efflux, accompanied by membrane depolarization, facilitates acute production of reactive oxygen species in phagocytosis. Belongs to the hydrogen channel family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, multi-pass; Membrane protein, integral; Channel, cation

Chromosomal Location of Human Ortholog: 12q24.11

Cellular Component: integral to membrane; integral to plasma membrane; plasma membrane

Molecular Function:voltage-gated cation channel activity; voltage-gated proton channel activity

Biological Process: proton transport; response to pH; response to zinc ion; sperm-egg recognition

NCBI Summary:This gene encodes a voltage-gated protein channel protein expressed more highly in certain cells of the immune system. Phagocytic cells produce superoxide anions which require this channel protein, and in B cells this same process facilitates antibody production. This same channel protein, however, can also regulate functions in other cells including spermatozoa. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
UniProt Code:Q96D96
NCBI GenInfo Identifier:74751810
NCBI Gene ID:84329
NCBI Accession:Q96D96.1
UniProt Secondary Accession:Q96D96,Q6UW11, Q96IS5, A8MQ37, B4DEB3, F8WCH5,
UniProt Related Accession:Q96D96
Molecular Weight:29,415 Da
NCBI Full Name:Voltage-gated hydrogen channel 1
NCBI Synonym Full Names:hydrogen voltage gated channel 1
NCBI Official Symbol:HVCN1  
NCBI Official Synonym Symbols:HV1; VSOP  
NCBI Protein Information:voltage-gated hydrogen channel 1
UniProt Protein Name:Voltage-gated hydrogen channel 1
UniProt Synonym Protein Names:Hydrogen voltage-gated channel 1; HV1; Voltage sensor domain-only protein
Protein Family:Voltage-gated hydrogen channel
UniProt Gene Name:HVCN1  
UniProt Entry Name:HVCN1_HUMAN
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