Cell Biology Antibodies 5
Anti-HUS1B Antibody (CAB14655)
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- SKU:
- CAB14655
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-HUS1B Antibody |
| Antibody SKU: | CAB14655 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-278 of human HUS1B (NP_683762.2). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse spleen, Mouse thymus |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-278 of human HUS1B (NP_683762.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MKFR AKIT GKGC LELF IHVS GTVA RLAK VCVL RVRP DSLC FGPA GSGG LHEA RLWC EVRQ GAFQ QFRM EGVS EDLD EIHL ELTA EHLS RAAR SAAG ASSL KLQL THKR RPSL TVAV ELVS SLGR ARSV VHDL PVRV LPRR VWRD CLPP SLRA SDAS IRLP RWRT LRSI VERM ANVG SHVL VEAN LSGR MTLS IETE VVSI QSYF KNLG NPPQ SAVG VPEN RDLE SMVQ VRVD NRKL LQFL EGQQ IHPT TALC NIWD NTLL QLVL VQED VSLQ YFIP AL |
| Gene ID: | 135458 |
| Uniprot: | Q8NHY5 |
| Cellular Location: | |
| Calculated MW: | 30kDa |
| Observed MW: | 30kDa |
| Synonyms: | HUS1B |
| Background: | The protein encoded by this gene is most closely related to HUS1, a component of a cell cycle checkpoint protein complex involved in cell cycle arrest in response to DNA damage. This protein can interact with the check point protein RAD1 but not with RAD9. Overexpression of this protein has been shown to induce cell death, which suggests a related but distinct role of this protein, as compared to the HUS1. |
| UniProt Protein Function: | HUS1B: is most closely related to HUS1, a component of a cell cycle checkpoint protein complex involved in cell cycle arrest in response to DNA damage. This protein can interact with the check point protein RAD1 but not with RAD9. Overexpression of this protein has been shown to induce cell death, which suggests a related but distinct role of this protein, as compared to the HUS1. [provided by RefSeq, Jul 2008] |
| UniProt Protein Details: | Protein type:Cell cycle regulation Chromosomal Location of Human Ortholog: 6p25.3 Cellular Component: nucleolus Biological Process: DNA damage checkpoint; DNA repair |
| NCBI Summary: | The protein encoded by this gene is most closely related to HUS1, a component of a cell cycle checkpoint protein complex involved in cell cycle arrest in response to DNA damage. This protein can interact with the check point protein RAD1 but not with RAD9. Overexpression of this protein has been shown to induce cell death, which suggests a related but distinct role of this protein, as compared to the HUS1. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q8NHY5 |
| NCBI GenInfo Identifier: | 311033394 |
| NCBI Gene ID: | 135458 |
| NCBI Accession: | Q8NHY5.2 |
| UniProt Secondary Accession: | Q8NHY5,Q5T4Z2, |
| UniProt Related Accession: | Q8NHY5 |
| Molecular Weight: | 278 |
| NCBI Full Name: | Checkpoint protein HUS1B |
| NCBI Synonym Full Names: | HUS1 checkpoint homolog b (S. pombe) |
| NCBI Official Symbol: | HUS1B |
| NCBI Protein Information: | checkpoint protein HUS1B; hHUS1B |
| UniProt Protein Name: | Checkpoint protein HUS1B |
| Protein Family: | Checkpoint protein |
| UniProt Gene Name: | HUS1B |
| UniProt Entry Name: | HUS1B_HUMAN |
 | Western blot analysis of extracts of various cell lines, using HUS1B antibody (CAB14655) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded rat testis using HUS1B antibody (CAB14655) at dilution of 1:100 (40x lens). |
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