Anti-Human IgG3 Antibody (CAB19713)
- SKU:
- CAB19713
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- IgG3
Description
| Product Name: | Human IgG3 Rabbit mAb |
| Product Code: | CAB19713 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | IgG3 |
| Applications: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human Human IgG3 |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | human plasma |
| Immunogen: | A synthesized peptide derived from human Human IgG3 |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 3502 |
| Uniprot: | P01860 |
| Calculated MW: | kDa |
| Observed MW: | 60KDa |
| UniProt Protein Function: | Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). |
| UniProt Code: | P01860 |
| NCBI GenInfo Identifier: | 193806361 |
| NCBI Gene ID: | 3502 |
| NCBI Accession: | P01860.2 |
| UniProt Secondary Accession: | P01860,A0A075B6N8, A2NU35, |
| UniProt Related Accession: | P01860 |
| Molecular Weight: | 41,287 Da |
| NCBI Full Name: | Immunoglobulin heavy constant gamma 3 |
| NCBI Synonym Full Names: | immunoglobulin heavy constant gamma 3 (G3m marker) |
| NCBI Official Symbol: | IGHG3 |
| NCBI Official Synonym Symbols: | IgG3 |
| UniProt Protein Name: | Immunoglobulin heavy constant gamma 3 |
| UniProt Synonym Protein Names: | HDC; Heavy chain disease protein; Ig gamma-3 chain C regionCurated |
| UniProt Gene Name: | IGHG3 |
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