Anti-Human CD195 (CCR5) - Purified Invivo Antibody

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SKU:
IVMB0304

Description

Product Name:Anti-Human CD195 (CCR5) - Purified Invivo Antibody
Product Code:IVMB0304
Clone:HEK/1/85a/7a
Protein:CD195
Product Type:Monoclonal Antibody
Synonyms:C-C chemokine receptor type 5, CC-CKR-5, CCR-5, CHEMR13, HIV-1 fusion coreceptor
Isotype:IgG2b k
Reactivity:Human
Applications:FC, ICC
Formulation:This purified antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Product Preparation:Functional grade preclinical antibodies are manufactured in an animal free facility using in vitro cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
Applications:FC, ICC
Reactivity:Human
Host Species:Rat
Specificity:Clone HEK/1/85a/7a recognizes an epitope on human CCR5.
Antigen Distribution:CCR5 is expressed on memory T cells, macrophages, and immature dendritic cells (DCs).
Immunogen:CHO cells transfected with full-length human CD195 (CCR5).
Concentration:0.5 mg/ml
Formulation:This purified antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Preparation:Functional grade preclinical antibodies are manufactured in an animal free facility using in vitro cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
Storage and Handling:This purified antibody is stable when stored at 2-8°C. Do not freeze.

CCR5 antibody, HEK/1/85a/7a, recognizes C-C chemokine receptor type 5 (CCR5), also known as CD195, CC-CKR-5, CHEMR13, and HIV-1 fusion coreceptor. CCR5 is a 45 kDa seven-transmembrane G-protein-coupled receptor (GPCR). CCR5 is expressed on a subset of memory T cells, macrophages, and immature dendritic cells (DCs) and is upregulated by proinflammatory cytokines1,2. CCR5 binds to inflammatory CC-chemokines, including CCL3 (macrophage inflammatory protein (MIP)-1α), CCL4 (MIP-1β), and RANTES, which increases intracellular calcium levels and results in cytoskeletal rearrangement and chemotactic cell migration3. CCR5 is also the coreceptor for HIV-1 following binding of viral gp120 to CD44-7. The levels of CCR5 on cells influence the rate of entry of HIV-1, and patients with lower levels of CCR5 exhibit immunity against infection8. CCR5 also contributes to other human diseases, including type I diabetes9 and cancer10.

Protein:CD195
Shipping:2-8°C
NCBI Gene Bank ID:1234
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Additional Information

Product Type:
In Vivo Monoclonal Antibody
Clone:
HEK/1/85a/7a
Protein:
CD195
Isotype:
IgG2b k
Reactivity:
Human
Synonyms:
C-C chemokine receptor type 5
Synonyms:
CC-CKR-5
Synonyms:
CCR-5
Synonyms:
CHEMR13
Synonyms:
HIV-1 fusion coreceptor
Host Species:
Rat
Applications:
FC
Applications:
ICC
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