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Product Name:	Anti-Human CD119 (IFN-γ R-α Chain) In Vivo Antibody - Ultra Low Endotoxin
Product Code:	IVMB0104
Size:	1mg, 5mg, 25mg, 50mg, 100mg
Clone:	GIR-208
Protein:	IFN-gamma R-alpha
Product Type:	Monoclonal Antibody
Synonyms:	IFNGR1, IFN-gamma R, IFN-gamma R-alpha, IFN-α R1, CDw119
Isotype:	Mouse IgG1
Reactivity:	Human
Immunogen:	Human IFN-gamma R-alpha, Purified from human placenta
Applications:	FA, FC
Formulation:	This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added.
Endotoxin Level:	<0.5 EU/mg as determined by the LAL method
Purity:	≥98% monomer by analytical SEC >95% by SDS Page
Preparation:	Functional grade preclinical antibodies are manufactured in an animal free facility using only In vitro protein free cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
Storage and Handling:	Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.

Product Code	Product Name	Endotoxin Level
IVMB0103	Anti-Human CD119 (IFN-gamma R-alpha Chain) In Vivo Antibody - Low Endotoxin	Low
IVMB0104	Anti-Human CD119 (IFN-γ Rα Chain) In Vivo Antibody - Ultra Low Endotoxin	Ultra Low

Applications:	FA, FC
Recommended Usage:	FC The suggested concentration for clone GIR-208 purified antibody for staining cells in flow cytometry is ≤ 0.5 µg per 10⁶ in a volume of 100 µl or 100µl of whole blood. Titration of the reagent is recommended for optimal performance for each application.
Reactivity:	Human

Host Species:	Mouse
Specificity:	Clone GIR-208 recognizes an epitope on human IFN-gamma R-alpha.
Antigen Distribution:	The IFN-gamma receptor is expressed at moderate levels on virtually every cell with the exception of erythrocytes.
Immunogen:	Human IFN-gamma R-alpha, Purified from human placenta
Concentration:	≥ 5.0 mg/ml
Endotoxin Level:	<0.5 EU/mg as determined by the LAL method
Purity:	≥98% monomer by analytical SEC >95% by SDS Page
Formulation:	This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added.
Preparation:	Functional grade preclinical antibodies are manufactured in an animal free facility using only In vitro protein free cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
Storage and Handling:	Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.

IFNγ Rα, or IFNγ R1, is a 90-100 kD type I transmembrane protein that is structurally related to IL-10 receptor. IFNγ Receptor consists of α and β chains and requires association of JAK1, JAK2 and Stat1 for IFN-γ signal transduction which induces tyrosine phosphorylation of IFN-γ Rα leading to the formation of a docking site on the activated receptor for Stat1, which specifically activates IFN-γ induced gene transcription.