Cell Biology Antibodies 4

Anti-HTRA4 Antibody (CAB14314)

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SKU:
CAB14314
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-HTRA4 Antibody
Antibody SKU:CAB14314
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 32-200 of human HTRA4 (NP_710159.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:U-87MG, U-251MG, Mouse brain, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 32-200 of human HTRA4 (NP_710159.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:EKLH TQPS CPAV CQPT RCPA LPTC ALGT TPVF DLCR CCRV CPAA EREV CGGA QGQP CAPG LQCL QPLR PGFP STCG CPTL GGAV CGSD RRTY PSMC ALRA ENRA ARRL GKVP AVPV QWGN CGDT GTRS AGPL RRNY NFIA AVVE KVAP SVVH VQLW GRLL HGSR LVPV Y
Gene ID:203100
Uniprot:P83105
Cellular Location:Secreted
Calculated MW:50kDa
Observed MW:51kDa
Synonyms:HTRA4
Background:This gene encodes a member of the HtrA family of proteases. The encoded protein contains a putative signal peptide, an insulin growth factor binding domain, a Kazal protease inhibitor domain, a conserved trypsin domain and a PDZ domain. Based on studies on other related family members, this enzyme may function as a secreted oligomeric chaperone protease to degrade misfolded secretory proteins. Other human HtrA proteins have been implicated in arthritis, tumor suppression, unfolded stress response, apoptosis, and aging.
UniProt Protein Function:HTRA4: Serine protease (Probable). Belongs to the peptidase S1B family.
UniProt Protein Details:

Protein type:Protease; Secreted, signal peptide; Secreted; EC 3.4.21.-

Chromosomal Location of Human Ortholog: 8p11.22

Cellular Component: extracellular region

Molecular Function:insulin-like growth factor binding; serine-type endopeptidase activity; endopeptidase activity

Biological Process: regulation of cell growth; proteolysis; negative regulation of transforming growth factor beta receptor signaling pathway

NCBI Summary:This gene encodes a member of the HtrA family of proteases. The encoded protein contains a putative signal peptide, an insulin growth factor binding domain, a Kazal protease inhibitor domain, a conserved trypsin domain and a PDZ domain. Based on studies on other related family members, this enzyme may function as a secreted oligomeric chaperone protease to degrade misfolded secretory proteins. Other human HtrA proteins have been implicated in arthritis, tumor suppression, unfolded stress response, apoptosis, and aging. [provided by RefSeq, Oct 2008]
UniProt Code:P83105
NCBI GenInfo Identifier:35505491
NCBI Gene ID:203100
NCBI Accession:AAH57765.1
UniProt Secondary Accession:P83105,Q542Z4, Q6PF13,
UniProt Related Accession:P83105
Molecular Weight:50,979 Da
NCBI Full Name:HtrA serine peptidase 4
NCBI Synonym Full Names:HtrA serine peptidase 4
NCBI Official Symbol:HTRA4  
NCBI Protein Information:serine protease HTRA4; probable serine protease HTRA4; high-temperature requirement factor A4
UniProt Protein Name:Serine protease HTRA4
UniProt Synonym Protein Names:High-temperature requirement factor A4
Protein Family:Serine protease
UniProt Gene Name:HTRA4  
UniProt Entry Name:HTRA4_HUMAN
Anti-HTRA4 Antibody (CAB14314)Western blot analysis of extracts of various cell lines, using HTRA4 antibody (CAB14314) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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