Cell Biology Antibodies 5

Anti-HTRA3 Antibody (CAB14649)

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SKU:
CAB14649
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-HTRA3 Antibody
Antibody SKU:CAB14649
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 334-453 of human HTRA3 (NP_444272.1).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, SW480, Mouse brain, Mouse heart, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 334-453 of human HTRA3 (NP_444272.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:SDRI TRFL TEFQ DKQI KDWK KRFI GIRM RTIT PSLV DELK ASNP DFPE VSSG IYVQ EVAP NSPS QRGG IQDG DIIV KVNG RPLV DSSE LQEA VLTE SPLL LEVR RGND DLLF SIAP EVVM
Gene ID:94031
Uniprot:P83110
Cellular Location:Secreted
Calculated MW:37kDa/48kDa
Observed MW:48kDa
Synonyms:HTRA3, Prsp, Tasp
Background:
UniProt Protein Function:HTRA3: Serine protease that cleaves beta-casein/CSN2 as well as several extracellular matrix (ECM) proteoglycans such as decorin/DCN, biglycan/BGN and fibronectin/FN1. Inhibits signaling mediated by TGF-beta family proteins possibly indirectly by degradation of these ECM proteoglycans. May act as a tumor suppressor. Negatively regulates, in vitro, trophoblast invasion during placental development and may be involved in the development of the placenta in vivo. May also have a role in ovarian development, granulosa cell differentiation and luteinization. Belongs to the peptidase S1B family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Secreted, signal peptide; EC 3.4.21.-; Secreted; Protease

Chromosomal Location of Human Ortholog: 4p16.1

Molecular Function:endopeptidase activity; protein binding; serine-type peptidase activity

Biological Process: negative regulation of BMP signaling pathway; negative regulation of transforming growth factor beta receptor signaling pathway; proteolysis

UniProt Code:P83110
NCBI GenInfo Identifier:21542412
NCBI Gene ID:94031
NCBI Accession:P83110.2
UniProt Secondary Accession:P83110,Q7Z7A2,
UniProt Related Accession:P83110
Molecular Weight:37,940 Da
NCBI Full Name:Serine protease HTRA3
NCBI Synonym Full Names:HtrA serine peptidase 3
NCBI Official Symbol:HTRA3  
NCBI Official Synonym Symbols:Prsp; Tasp  
NCBI Protein Information:serine protease HTRA3
UniProt Protein Name:Serine protease HTRA3
UniProt Synonym Protein Names:High-temperature requirement factor A3; Pregnancy-related serine protease
Protein Family:Serine protease
UniProt Gene Name:HTRA3  
UniProt Entry Name:HTRA3_HUMAN
Anti-HTRA3 Antibody (CAB14649)Western blot analysis of extracts of various cell lines, using HTRA3 antibody (CAB14649) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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