Anti-HTR2A Antibody (CAB20538)

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SKU:
CAB20538

Description

Product Name:HTR2A Rabbit pAb
Product Code:CAB20538
Size:50uL, 100uL
Synonyms:HTR2, 5-HT2A
Applications:WB, IF
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant protein of human HTR2A.
Applications:WB, IF
Recommended Dilutions:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse
Positive Samples:SH-SY5Y, Mouse brain
Immunogen:Recombinant protein of human HTR2A.
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:3356
Uniprot:P28223
Calculated MW:52kDa
Observed MW:53KDa
UniProt Protein Function:5-HT(2A): This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. This receptor is involved in tracheal smooth muscle contraction, bronchoconstriction, and control of aldosterone production. Belongs to the G-protein coupled receptor 1 family. Protein type: Membrane protein, integral; GPCR, family 1; Receptor, GPCR; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 13q14-q21 Cellular Component: cell soma; axon; integral to plasma membrane; cytoplasmic membrane-bound vesicle; plasma membrane; dendritic shaft; caveola; cytosol Molecular Function: serotonin binding; serotonin receptor activity; protein complex binding; G-protein alpha-subunit binding; drug binding Biological Process: cell death; urinary bladder smooth muscle contraction; phosphoinositide 3-kinase cascade; negative regulation of potassium ion transport; thermoregulation; regulation of dopamine secretion; positive regulation of MAP kinase activity; synaptic transmission; behavioral response to cocaine; positive regulation of cell proliferation; detection of temperature stimulus involved in sensory perception of pain; artery smooth muscle contraction; serotonin receptor signaling pathway; regulation of behavior; aging; response to drug; serotonin receptor, phospholipase C activating pathway; regulation of hormone secretion; negative regulation of synaptic transmission, glutamatergic; positive regulation of phosphatidylinositol biosynthetic process; sleep; memory; cellular calcium ion homeostasis; detection of mechanical stimulus involved in sensory perception of pain; positive regulation of peptidyl-tyrosine phosphorylation; phospholipase C activation; release of sequestered calcium ion into cytosol; positive regulation of glycolysis; positive regulation of vasoconstriction; positive regulation of fat cell differentiation Disease: Schizophrenia; Alcohol Dependence; Anorexia Nervosa, Susceptibility To, 1; Obsessive-compulsive Disorder; Major Depressive Disorder
UniProt Protein Details:
NCBI Summary:This gene encodes one of the receptors for serotonin, a neurotransmitter with many roles. Mutations in this gene are associated with susceptibility to schizophrenia and obsessive-compulsive disorder, and are also associated with response to the antidepressant citalopram in patients with major depressive disorder (MDD). MDD patients who also have a mutation in intron 2 of this gene show a significantly reduced response to citalopram as this antidepressant downregulates expression of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
UniProt Code:P28223
NCBI GenInfo Identifier:543727
NCBI Gene ID:3356
NCBI Accession:P28223.2
UniProt Secondary Accession:P28223,Q5T8C0, B2RAC5, B4DZ79, F5GWE8
UniProt Related Accession:P28223
Molecular Weight:
NCBI Full Name:5-hydroxytryptamine receptor 2A
NCBI Synonym Full Names:5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
NCBI Official Symbol:HTR2A  
NCBI Official Synonym Symbols:HTR2; 5-HT2A  
NCBI Protein Information:5-hydroxytryptamine receptor 2A; 5-HT-2A; 5-HT2 receptor; serotonin 5-HT-2A receptor
UniProt Protein Name:5-hydroxytryptamine receptor 2A
UniProt Synonym Protein Names:Serotonin receptor 2A
Protein Family:
UniProt Gene Name:HTR2A  
UniProt Entry Name:5HT2A_HUMAN
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Additional Information

Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
HTR2
Synonyms:
5-HT2A
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