Cell Biology Antibodies 18

Anti-HTR1B Antibody (CAB18285)

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SKU:
CAB18285
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-HTR1B Antibody
Antibody SKU:CAB18285
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant protein of human HTR1B.
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:mouse brain, rat brain
Immunogen:Recombinant protein of human HTR1B.
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:3351
Uniprot:P28222
Cellular Location:
Calculated MW:44kDa
Observed MW:44kDa
Anti-HTR1B Antibody (CAB18285)Western blot - HTR1B Rabbit pAb (CAB18285)
Synonyms:S12, 5-HT1B, HTR1D2, HTR1DB, 5-HT-1B, 5-HT1DB, 5-HT-1D-beta, HTR1B
Background:The protein encoded by this intronless gene is a G-protein coupled receptor for serotonin (5-hydroxytryptamine). Ligand binding activates second messengers that inhibit the activity of adenylate cyclase and manage the release of serotonin, dopamine, and acetylcholine in the brain. The encoded protein may be involved in several neuropsychiatric disorders and therefore is often a target of antidepressant and other psychotherapeutic drugs.
UniProt Protein Function:5-HT(1B): This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Belongs to the G-protein coupled receptor 1 family.
UniProt Protein Details:

Protein type:Receptor, GPCR; GPCR, family 1; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 6q13

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function:protein binding; serotonin receptor activity

Biological Process: G-protein signaling, coupled to cyclic nucleotide second messenger; negative regulation of cAMP biosynthetic process; negative regulation of serotonin secretion; serotonin receptor, adenylate cyclase inhibiting pathway

NCBI Summary:The protein encoded by this intronless gene is a G-protein coupled receptor for serotonin (5-hydroxytryptamine). Ligand binding activates second messengers that inhibit the activity of adenylate cyclase and manage the release of serotonin, dopamine, and acetylcholine in the brain. The encoded protein may be involved in several neuropsychiatric disorders and therefore is often a target of antidepressant and other psychotherapeutic drugs. [provided by RefSeq, Nov 2015]
UniProt Code:P28222
NCBI GenInfo Identifier:112821
NCBI Gene ID:3351
NCBI Accession:P28222.1
UniProt Secondary Accession:P28222,Q4VAY7,
UniProt Related Accession:P28222
Molecular Weight:43,568 Da
NCBI Full Name:5-hydroxytryptamine receptor 1B
NCBI Synonym Full Names:5-hydroxytryptamine receptor 1B
NCBI Official Symbol:HTR1B  
NCBI Official Synonym Symbols:S12; 5-HT1B; HTR1D2; HTR1DB; 5-HT-1B; 5-HT1DB; 5-HT-1D-beta  
NCBI Protein Information:5-hydroxytryptamine receptor 1B
UniProt Protein Name:5-hydroxytryptamine receptor 1B
UniProt Synonym Protein Names:S12; Serotonin 1D beta receptor; 5-HT-1D-beta; Serotonin receptor 1B
Protein Family:5-hydroxytryptamine receptor
UniProt Gene Name:HTR1B  
UniProt Entry Name:5HT1B_HUMAN
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