Cardiovascular Antibodies

Anti-HTATIP2 Antibody (CAB5816)

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SKU:
CAB5816
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cardiovascular

Description

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Antibody Name:Anti-HTATIP2 Antibody
Antibody SKU:CAB5816
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 100 to the C-terminus of human HTATIP2 (NP_006401.3).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:LO2
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 100 to the C-terminus of human HTATIP2 (NP_006401.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:GAEG FVRV DRDY VLKS AELA KAGG CKHF NLLS SKGA DKSS NFLY LQVK GEVE AKVE ELKF DRYS VFRP GVLL CDRQ ESRP GEWL VRKF FGSL PDSW ASGH SVPV VTVV RAML NNVV RPRD KQME LLEN KAIH DLGK AHGS LKP
Gene ID:10553
Uniprot:Q9BUP3
Cellular Location:Cytoplasm, Nucleus envelope
Calculated MW:14kDa/27kDa/30kDa
Observed MW:27kDa
Synonyms:HTATIP2, CC3, SDR44U1, TIP30
Background:
UniProt Protein Function:HTATIP2: Oxidoreductase required for tumor suppression. NAPDH- bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import. Isoform 1 is a metastasis suppressor with proapoptotic as well as antiangiogenic properties. Isoform 2 has an antiapoptotic effect. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Oxidoreductase; Apoptosis; Tumor suppressor; Nuclear envelope; Transcription factor; EC 1.1.1.-

Chromosomal Location of Human Ortholog: 11p15.1

Cellular Component: membrane; cytoplasm; nuclear envelope; nucleus

Molecular Function:protein binding; transcription coactivator activity; oxidoreductase activity

Biological Process: regulation of transcription from RNA polymerase II promoter; viral reproduction; apoptosis; nuclear import; angiogenesis; cell differentiation; regulation of angiogenesis; negative regulation of apoptosis

UniProt Code:Q9BUP3
NCBI GenInfo Identifier:317373366
NCBI Gene ID:10553
NCBI Accession:Q9BUP3.2
UniProt Secondary Accession:Q9BUP3,O15383, O60520, O95345, Q53GC1, Q53GG2, Q6IBI3 A8K7S7, D3DQY8,
UniProt Related Accession:Q9BUP3
Molecular Weight:242
NCBI Full Name:Oxidoreductase HTATIP2
NCBI Synonym Full Names:HIV-1 Tat interactive protein 2, 30kDa
NCBI Official Symbol:HTATIP2  
NCBI Official Synonym Symbols:CC3; TIP30; SDR44U1  
NCBI Protein Information:oxidoreductase HTATIP2; Tat-interacting protein (30kD); HIV-1 TAT-interactive protein 2; 30 kDa HIV-1 TAT-interacting protein; short chain dehydrogenase/reductase family 44U, member 1
UniProt Protein Name:Oxidoreductase HTATIP2
UniProt Synonym Protein Names:30 kDa HIV-1 TAT-interacting protein; HIV-1 TAT-interactive protein 2
Protein Family:Oxidoreductase
UniProt Gene Name:HTATIP2  
UniProt Entry Name:HTAI2_HUMAN
Anti-HTATIP2 Antibody (CAB5816)Western blot analysis of extracts of LO2 cells, using HTATIP2 antibody (CAB5816) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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