Metabolism Antibodies 2

Anti-HSPH1 Antibody (CAB6622)

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SKU:
CAB6622
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Metabolism

Description

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Antibody Name:Anti-HSPH1 Antibody
Antibody SKU:CAB6622
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 659-858 of human HSPH1 (NP_006635.2).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:MCF7, BT-474, HepG2, 293T, U-251MG, Mouse brain, Mouse kidney, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 659-858 of human HSPH1 (NP_006635.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:EQDH QNFL RLLT ETED WLYE EGED QAKQ AYVD KLEE LMKI GTPV KVRF QEAE ERPK MFEE LGQR LQHY AKIA ADFR NKDE KYNH IDES EMKK VEKS VNEV MEWM NNVM NAQA KKSL DQDP VVRA QEIK TKIK ELNN TCEP VVTQ PKPK IESP KLER TPNG PNID KKEE DLED KNNF GAEP PHQN GECY PNEK NSVN MDLD
Gene ID:10808
Uniprot:Q92598
Cellular Location:Cytoplasm
Calculated MW:92kDa/96kDa/97kDa
Observed MW:120kDa
Synonyms:HSPH1, HSP105, HSP105A, HSP105B, NY-CO-25
Background:This gene encodes a member of the heat shock protein 70 family of proteins. The encoded protein functions as a nucleotide exchange factor for the molecular chaperone heat shock cognate 71 kDa protein (Hsc70). In addition, this protein plays a distinct but related role as a holdase that inhibits the aggregation of misfolded proteins, including the cystic fibrosis transmembrane conductance regulator (CFTR) protein. Elevated expression of this protein has been observed in numerous human cancers.
UniProt Protein Function:HSP105: a molecular chaperone of the heat shock protein 70 family. Has ATPase activity. Expressed at especially high levels in mammalian brain and has been shown to suppress apoptosis in neuronal cells and to prevent the aggregation of proteins following heat shock. Known to interact with a variety of proteins including alpha-tubulin and the androgen receptor. Two alternatively spliced isoforms have been described.
UniProt Protein Details:

Protein type:Heat shock protein; Chaperone

Chromosomal Location of Human Ortholog: 13q12.3

Cellular Component: nucleoplasm; microtubule; cytoplasm; extracellular region; cytosol

Molecular Function:protein binding; ATP binding; alpha-tubulin binding

Biological Process: receptor-mediated endocytosis; positive regulation of NK T cell activation; chaperone cofactor-dependent protein folding; positive regulation of MHC class I biosynthetic process; response to unfolded protein

UniProt Code:Q92598
NCBI GenInfo Identifier:2495344
NCBI Gene ID:10808
NCBI Accession:Q92598.1
UniProt Secondary Accession:Q92598,O95739, Q5TBM6, Q5TBM7, Q5TBM8, Q9UPC4, B4DYH1
UniProt Related Accession:Q92598
Molecular Weight:97,460 Da
NCBI Full Name:Heat shock protein 105 kDa
NCBI Synonym Full Names:heat shock 105kDa/110kDa protein 1
NCBI Official Symbol:HSPH1  
NCBI Official Synonym Symbols:HSP105; HSP105A; HSP105B; NY-CO-25  
NCBI Protein Information:heat shock protein 105 kDa; antigen NY-CO-25; heat shock 105kD beta; heat shock 105kD alpha
UniProt Protein Name:Heat shock protein 105 kDa
UniProt Synonym Protein Names:Antigen NY-CO-25; Heat shock 110 kDa protein
Protein Family:Heat shock protein
UniProt Gene Name:HSPH1  
UniProt Entry Name:HS105_HUMAN
Anti-HSPH1 Antibody (CAB6622)Western blot analysis of extracts of various cell lines, using HSPH1 antibody (CAB6622) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s.
Anti-HSPH1 Antibody (CAB6622)Immunohistochemistry of paraffin-embedded rat fallopian tube using HSPH1 antibody (CAB6622) at dilution of 1:100 (40x lens).
Anti-HSPH1 Antibody (CAB6622)Immunohistochemistry of paraffin-embedded human tonsil using HSPH1 antibody (CAB6622) at dilution of 1:100 (40x lens).
Anti-HSPH1 Antibody (CAB6622)Immunohistochemistry of paraffin-embedded mouse spinal cord using HSPH1 antibody (CAB6622) at dilution of 1:100 (40x lens).
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