KO Validated Antibodies 2

Anti-HSPH1 Antibody (CAB19914)[KO Validated]

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SKU:
CAB19914
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Metabolism

Description

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Antibody Name:Anti-HSPH1 Antibody [KO Validated]
Antibody SKU:CAB19914
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant protein of human HSPH1.
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:293T
Immunogen:Recombinant protein of human HSPH1.
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:10808
Uniprot:Q92598
Cellular Location:Cytoplasm
Calculated MW:92kDa/96kDa/97kDa
Observed MW:97KDa
Anti-HSPH1 Antibody [KO Validated] (CAB19914)Western blot analysis of extracts from normal (control) and HSPH1 knockout (KO) 293T cells, using HSPH1 antibody (CAB19914) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
Synonyms:HSPH1, HSP105, HSP105A, HSP105B, NY-CO-25
Background:This gene encodes a member of the heat shock protein 70 family of proteins. The encoded protein functions as a nucleotide exchange factor for the molecular chaperone heat shock cognate 71 kDa protein (Hsc70). In addition, this protein plays a distinct but related role as a holdase that inhibits the aggregation of misfolded proteins, including the cystic fibrosis transmembrane conductance regulator (CFTR) protein. Elevated expression of this protein has been observed in numerous human cancers.
UniProt Protein Function:HSP105: a molecular chaperone of the heat shock protein 70 family. Has ATPase activity. Expressed at especially high levels in mammalian brain and has been shown to suppress apoptosis in neuronal cells and to prevent the aggregation of proteins following heat shock. Known to interact with a variety of proteins including alpha-tubulin and the androgen receptor. Two alternatively spliced isoforms have been described.
UniProt Protein Details:

Protein type:Heat shock protein; Chaperone

Chromosomal Location of Human Ortholog: 13q12.3

Cellular Component: nucleoplasm; microtubule; cytoplasm; extracellular region; cytosol

Molecular Function:protein binding; ATP binding; alpha-tubulin binding

Biological Process: receptor-mediated endocytosis; positive regulation of NK T cell activation; chaperone cofactor-dependent protein folding; positive regulation of MHC class I biosynthetic process; response to unfolded protein

UniProt Code:Q92598
NCBI GenInfo Identifier:2495344
NCBI Gene ID:10808
NCBI Accession:Q92598.1
UniProt Secondary Accession:Q92598,O95739, Q5TBM6, Q5TBM7, Q5TBM8, Q9UPC4, B4DYH1
UniProt Related Accession:Q92598
Molecular Weight:97,460 Da
NCBI Full Name:Heat shock protein 105 kDa
NCBI Synonym Full Names:heat shock 105kDa/110kDa protein 1
NCBI Official Symbol:HSPH1  
NCBI Official Synonym Symbols:HSP105; HSP105A; HSP105B; NY-CO-25  
NCBI Protein Information:heat shock protein 105 kDa; antigen NY-CO-25; heat shock 105kD beta; heat shock 105kD alpha
UniProt Protein Name:Heat shock protein 105 kDa
UniProt Synonym Protein Names:Antigen NY-CO-25; Heat shock 110 kDa protein
Protein Family:Heat shock protein
UniProt Gene Name:HSPH1  
UniProt Entry Name:HS105_HUMAN
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